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by aphorist
Sat Sep 28, 2019 9:51 am
Forum: Science and Research
Topic: Lifelong choline supplementation ameliorates Alzheimer’s disease pathology ...
Replies: 3
Views: 896

Re: Lifelong choline supplementation ameliorates Alzheimer’s disease pathology ...

I understand the need to demonstrate proof of concept in these studies. But the HED of 28 grams per day of choline is kind of annoying. This is a pretty insightful comment I saw regarding this paper: It's pretty simple actually, both conditions can be traced back to the inability of small blood vess...
by aphorist
Mon Sep 23, 2019 6:07 pm
Forum: Prevention and Treatment
Topic: Does Alzheimers show up on an MRI?
Replies: 6
Views: 1116

Re: Does Alzheimers show up on an MRI?

I'm not well versed enough about the radiology of diagnosing Alzheimer's. But if the hippocampal volume is good and nothing looks amiss in the entorhinal cortex, then it might be some other type of dementia. Maybe FTD. Can't say with certainty though. AFAIK, you can't see plaques or tangles on an MR...
by aphorist
Sun Sep 22, 2019 1:38 pm
Forum: Science and Research
Topic: Clusterin / ApoJ
Replies: 2
Views: 688

Clusterin / ApoJ

https://www.biorxiv.org/content/10.1101/775288v1.full This study may be a bit much for people, but I think it's interesting. They basically took 'runner mice', extracted their plasma, and injected it into sedentary controls. They determined 'runner plasma' (RP) and key constituents including Cluster...
by aphorist
Thu Jun 27, 2019 7:29 am
Forum: Science and Research
Topic: HDL from an Alzheimer's disease perspective
Replies: 2
Views: 903

Re: HDL from an Alzheimer's disease perspective

Your second link re. functionality gets to the heart of the HDL issue. That said, I'm waiting for a "functionality" biomarker for HDL. What's the best we've got? This is an important question. I think the best answer is to measure Paraoxonase-1 (PON1) levels. Paraoxonase 1 (PON1) is an es...
by aphorist
Wed Jun 26, 2019 8:57 am
Forum: Prevention and Treatment
Topic: High cortisol
Replies: 11
Views: 2053

Re: High cortisol

I’m wondering how adrenal weakness and high cortisol go hand in hand. In true medical adrenal insufficiency the adrenals stop producing cortisol altogether. It can be life threatening in certain scenarios of physiological stress. If you’re concluding you have some adrenal weakness of some kind base...
by aphorist
Sat May 11, 2019 9:30 am
Forum: Prevention and Treatment
Topic: Ketone meters
Replies: 16
Views: 3229

Re: Ketone meters

That's a good idea to search for Ketone strips on eBay :idea: I get glucometer and ketone strips off Ebay at fairly cheap prices. I'm not sure exactly where these strips are coming from, in the case of certain vendors. I know there is some kind of underground black market for medicaid diabetes pati...
by aphorist
Mon May 06, 2019 10:12 am
Forum: Prevention and Treatment
Topic: Ketone meters
Replies: 16
Views: 3229

Re: Ketone meters

I use Abbott Precision. Everyone seems to say that Keto Mojo strips are cheaper, but I don't see that or understand. You can get strips on amazon or ebay at $1.00/ea or less.
by aphorist
Sun May 05, 2019 7:47 am
Forum: Science and Research
Topic: Plasmalogens- exciting new evidence
Replies: 142
Views: 37267

Re: Plasmalogens- exciting new evidence

Because the authors chose to transform all of their participants data in this way, readers cannot simply calculate their HDL-R number and go to the charts to see where they might be. They need to do this needlessly complicated transform process! I think they did this to create normally distributed ...

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