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by Matisse
Wed Apr 29, 2015 12:17 pm
Forum: Prevention and Treatment
Topic: COMT rs4680 and Placebo Response
Replies: 0
Views: 789

COMT rs4680 and Placebo Response

From a new study: "Patients homozygous for the rs4680 low-activity met allele (met/met), known to have high levels of dopamine, had the greatest placebo response. The high-activity val allele homozygous (val/val) patients had the lowest placebo response." Met/met is AA. Val/val is GG. Here...
by Matisse
Thu Apr 02, 2015 1:43 pm
Forum: Our Stories
Topic: Advice? Support? Info?
Replies: 22
Views: 4826

Re: Advice? Support? Info?

RS4420638 is another snp that is in strong but not perfect LD with apoe. Usually apoe3/3 is AA but some people with apoe3/4 are also AA. It doesn't tend to go the other way however -- that is someone who is 3/3 will not be AG.
by Matisse
Wed Nov 26, 2014 2:27 pm
Forum: Prevention and Treatment
Topic: Psen2 Clinical trials
Replies: 7
Views: 1716

Re: Psen2 Clinical trials

I actually have a PSEN1 mutation of possible concern, no PSEN2s. No history of early onset dementia in my family and I'm 64. Just wondering whether Doc got any more info on the PSENs.
by Matisse
Tue Nov 25, 2014 7:21 pm
Forum: Prevention and Treatment
Topic: Psen2 Clinical trials
Replies: 7
Views: 1716

Re: Psen2 Clinical trials

Doc,

Did you ever pursue the study at the U of Washington. I also have a PSEN mutation -- not sure how serious it is -- but am still concerned so I'm wondering what your experience has been with them. Thanks.

Matisse
by Matisse
Mon Nov 03, 2014 12:37 pm
Forum: Prevention and Treatment
Topic: A strange tale on supplemtation
Replies: 20
Views: 5782

Re: A strange tale on supplemtation

JanPeter,

Have you looked at your snps related to methylation especially the serotonin/dopamine ones?

http://geneticgenie.org/methylation-analysis-example/

Matisse
by Matisse
Sat Jul 19, 2014 2:23 pm
Forum: Prevention and Treatment
Topic: Coupon for MDLabTests.com?
Replies: 5
Views: 1531

Re: Coupon for MDLabTests.com?

Skibike wrote:Your timing sucks as this must be the first weekend in like forever that they didn't send out a coupon! :D

Based on your experience with the coupon codes is it likely they'll have another one next weekend? I have just over $200 in testing I want done so if I wait I could save a few $$.
by Matisse
Sat Jul 19, 2014 10:14 am
Forum: Prevention and Treatment
Topic: Coupon for MDLabTests.com?
Replies: 5
Views: 1531

Coupon for MDLabTests.com?

Anyone have a coupon? Everything I find on the net expired on 7/13 or doesn't work. Thanks.
by Matisse
Fri Jul 18, 2014 7:14 pm
Forum: Prevention and Treatment
Topic: The Protective Allele Study - Full Paper
Replies: 15
Views: 3537

Re: The Protective Allele Study - Full Paper

HAHAHA! I did, Jul! :lol: I also just wrote this dude (I shorthanded it, I swear): https://oraprdnt.uqtr.uquebec.ca/pls/public/genw050.afficher_fiche_perso?owa_cd_secteur=0800&owa_cd_fonction=1&owa_no_personne=548835&owa_contexte=$2343-37 One of the study's contributors. I told him all ...
by Matisse
Wed Jul 16, 2014 7:14 pm
Forum: Prevention and Treatment
Topic: Protective Allele
Replies: 16
Views: 3599

Protective Allele

RS3846662AA is protective and fairly common. I'm heterozygous. http://www.nature.com/mp/journal/vaop/ncurrent/full/mp201481a.html HMGCR is a genetic modifier for risk, age of onset and MCI conversion to Alzheimer’s disease in a three cohorts study V Leduc, L De Beaumont, L Théroux, D Dea, P Aisen, R...
by Matisse
Thu Jul 10, 2014 4:39 pm
Forum: Prevention and Treatment
Topic: King's College London and Oxford University blood test
Replies: 6
Views: 1514

Re: King's College London and Oxford University blood test

From what I've read (see article below) these tests seem pretty worthless because of high false positives and overall unreliability: HypeWatch: Another Dementia Blood Test Oversold Published: Jul 8, 2014 By John Gever, Deputy Managing Editor, MedPage Today Another study of a potential blood test to ...

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