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by NF52
Sun Nov 12, 2017 10:06 am
Forum: Our Stories
Topic: Hello, new, very new, found out 4/4 today
Replies: 4
Views: 961

Re: Hello, new, very new, found out 4/4 today

Eva, A quick addition: my lipids too looked like "crap". Numbers of LDL-P in the stratosphere, and Lp(a) beyond the chart of "high risk" of coronary artery disease. So I recently paid for a coronary artery calcium scan, due to concern that maybe my family history of stroke and he...
by NF52
Sun Nov 12, 2017 9:59 am
Forum: Our Stories
Topic: Hello, new, very new, found out 4/4 today
Replies: 4
Views: 961

Re: Hello, new, very new, found out 4/4 today

Welcome Eva, I want to offer support as someone who also is a 4/4, found out accidentally at almost age 62, and is now 65 and feeling much more confident about my chances of having many more years of healthy, happy living. I agree with Jan's assessment of your cognitive reserve. One community-based ...
by NF52
Sat Nov 11, 2017 8:35 am
Forum: Science and Research
Topic: Apolipoprotein E and Alzheimer disease: risk, mechanisms, and therapy
Replies: 15
Views: 4408

Re: Apolipoprotein E and Alzheimer disease: risk, mechanisms, and therapy

Thanks Julie,
I am also humbled by the depth of knowledge of you and many others on this site, and the commitment to sharing stories, support and strategies. Lots of paths to plugging those holes in the roof--even it some of us have steeper roofs and more holes!
by NF52
Sat Nov 11, 2017 8:32 am
Forum: Science and Research
Topic: E4 combinations
Replies: 3
Views: 1257

Re: E4 combinations

Hi Sarahb12 and orangeblossom, Good question about whether one copy of ApoE 3 "ameliorates" the effect of one coy of ApoE 4! I think the consensus is that ApoE 4 is what is sometimes called "dose-dependent", meaning that in this case having two copies confers more risk, rather th...
by NF52
Sat Nov 11, 2017 7:41 am
Forum: Science and Research
Topic: Apolipoprotein E and Alzheimer disease: risk, mechanisms, and therapy
Replies: 15
Views: 4408

Re: Apolipoprotein E and Alzheimer disease: risk, mechanisms, and therapy

Stavia, Here's the relevant quote from the PLOS study: (embedded in the longer quote at the end of this post. The Generation Study elected to disclose the following “lifetime” risks of MCI or dementia to its potential participants: 30%–55% for individuals with APOE-e4/e4; 20%–25% for individuals wit...
by NF52
Thu Nov 09, 2017 8:44 am
Forum: Our Stories
Topic: Diet for elderly mom who does NOT need to lose weight.
Replies: 28
Views: 6800

Re: Diet for elderly mom who does NOT need to lose weight.

Hi acornstwo, Because your mom has "blood platelet problems", has her hematologist or PCP suggested that she has vascular dementia rather than "classic" Alzheimer's. If so, and if she is at risk of micro-bleeds or vascular ischemic events in the brain, it may be helpful to ask th...
by NF52
Thu Nov 09, 2017 8:17 am
Forum: Getting Started
Topic: Overwhelmed 4/4 Looking for Path Forward
Replies: 12
Views: 4030

Re: Overwhelmed 4/4 Looking for Path Forward

Hi Greg, I have an almost-36 year old son who is very similar to you in build and is a 3/4. He's also a guy who had heart surgery to correct a congenital anomaly when he was 5 years old, so cardiologists would probably suggest all sorts of things for him. (He chooses not be followed by one for now.)...
by NF52
Tue Nov 07, 2017 11:31 am
Forum: Our Stories
Topic: New member
Replies: 6
Views: 1564

Re: New member

Hi DefyingErasure, I too am an ApoE 4/4, now 65 and can certainly remember being the feeling of being gob-smacked (or gut-punched) when I learned my status from 23 & me 3 years ago. There are a number of us in this age group, and like you we are learning how to live well, love well and laugh oft...
by NF52
Fri Nov 03, 2017 12:37 pm
Forum: Prevention and Treatment
Topic: ? about Niacin and lipids
Replies: 19
Views: 5623

Re: ? about Niacin and lipids

I have problematic lipids with high LDL P levels. In fact, my athletic brother died at 56 (E3/E4) due to sudden cardiac death and my father has CAD (quadruple bypass). Hi cwicker, I also have high LDL-P levels (they used to be sky-high (above 2200) but dropped in half after 6 months on 10 mg atorva...
by NF52
Fri Nov 03, 2017 12:18 pm
Forum: Our Stories
Topic: Newbie
Replies: 12
Views: 2704

Re: Newbie

Hi acornstwo! Like you, I am in my 60's (smack in the middle!) and had a mother who had dementia or in her 80's, after her 4 older sisters went down that same path, and a father who died of heart disease at age 67. I found out about my 4/4 status the "old-fashioned way"--getting a 23&m...

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