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by NF52
Thu Jun 22, 2017 8:20 am
Forum: Our Stories
Topic: New here...apoe4/4
Replies: 3
Views: 1085

Re: New here...apoe4/4

Hi Eliza, I'm so sorry that you lost your parents when they (and you) were so young. Like you, my dad died too early of late-diagnosed coronary artery disease when I was 34. At age 41, I also had 3 little ones. Like you, I found out "accidentally" that I was a 4/4 from 23&me three year...
by NF52
Mon Jun 05, 2017 9:20 am
Forum: Prevention and Treatment
Topic: can those in contact with dr bredesen ask why there is no research being done on the prevention of ftd?
Replies: 1
Views: 852

Re: can those in contact with dr bredesen ask why there is no research being done on the prevention of ftd?

Hi "Pro", I'm sorry that you've had no luck with finding information on prevention trials for FTD. Here is a link to Clinical Trials.gov, a site that shows both U.S and other countries' clinical trials related to FTD. Many of these studies have been completed; others appear to be intervent...
by NF52
Fri Jun 02, 2017 1:18 pm
Forum: Prevention and Treatment
Topic: awake for colonoscopy?
Replies: 36
Views: 6590

Re: awake for colonoscopy?

Just to add some additional color commentary: I think it's not just the "corners" or width of the abdomen that leads to pain. I have diverticulosis, which was only identified during my first colonoscopy. During the second in 2015, with IV pain medication in place, I quickly had intense pai...
by NF52
Fri May 26, 2017 4:01 pm
Forum: Our Stories
Topic: Overwhelmed with genetic data
Replies: 11
Views: 3076

Re: Overwhelmed with genetic data

Welcome "Kate", Like you, our first son brought us delight and a whole lot of medical stuff we didn't expect. He diagnosed shortly after birth with multiple congenital anomalies (not genetic in this case), and had his first life-saving surgery at one day old, followed by another at 5 weeks...
by NF52
Fri May 26, 2017 8:13 am
Forum: Our Stories
Topic: New here- My story and my current labs
Replies: 6
Views: 1796

Re: New here- My story and my current labs

Hi Noogie, As someone who has known lots of wonderful, unique people with ADHD and Asperger's, I think you have some advantages in this world of APOE 4! I'm guessing that you figured out on your own as an adult that you have ADHD and Asperger's, since Asperger's has only been talked about in the U.S...
by NF52
Wed May 24, 2017 1:50 pm
Forum: Science and Research
Topic: TOMM40 effect elucidated?
Replies: 2
Views: 1157

Re: TOMM40 effect elucidated?

Thanks for linking to this, Julie! The abstract was tantalizing enough for me to pay for full access. Background for those like me who were clueless about this: Of the three variations in this SNP rs6265, , Val/Val is more common (67.7% of those in this study), while 28.9% were Val/Met and 3.3% were...
by NF52
Fri May 19, 2017 8:14 am
Forum: Our Stories
Topic: New Here
Replies: 32
Views: 6206

Re: New Here

Gemma, Here's the link and quote that I mentioned in the previous post: "For APOE4 carriers with high lifetime intellectual enrichment (75th percentile of education/occupation score and midlife to late-life cognitive activity), the onset of cognitive impairment was approximately 8.7 years later...
by NF52
Fri May 19, 2017 6:38 am
Forum: Our Stories
Topic: New Here
Replies: 32
Views: 6206

Re: New Here

Welcome, Gemma! You already are showing one of the best strategies possible: a sense of humor and irony about finding out your 4/4 status when you are 44! I have a 4/4 birthday and always loved the symmetry of that--especially the year I turned 44 on 4/4. Like you, the irony of finding out I also am...
by NF52
Fri May 12, 2017 6:20 pm
Forum: Prevention and Treatment
Topic: Parkinsons
Replies: 12
Views: 2730

Re: Parkinsons

Stavia, Your question on current best practice for cognitive rehab is excellent--and sadly, the field lacks consistent terminology and application guidelines for many terms used widely. This may be overkill, but here are a few references that highlight memory re-training, metacognitive strategy inst...
by NF52
Fri May 12, 2017 5:53 pm
Forum: Science and Research
Topic: New paper suggests that statins may be beneficial for E4 homozygotes
Replies: 45
Views: 10539

Re: New paper suggests that statins may be beneficial for E4 homozygotes

I hesitate to jump into such a fraught topic, but an "old" small, but randomized, one-year study from 2006 also suggests benefit for 3/4s or 4/4s diagnosed as in the mild-moderate range of Alzheimers for an 80 mg/day dose of atorvastatin. Here's the citation and link: Sparks, D. L., et al....

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