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by Fiver
Wed Jan 06, 2021 10:45 am
Forum: Getting Started
Topic: STATINs
Replies: 5
Views: 578

Re: STATINs

From my experience I totally agree with the usefulness of the coronary calcium score. I think we'll see this become even more common and accessible in the near future. It was such a relief to get my score. And unusual - how many accurate tests are there we can count on currently? Just one minor thin...
by Fiver
Mon Oct 26, 2020 6:09 am
Forum: Science and Research
Topic: APOΕ4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis
Replies: 23
Views: 2693

Re: APOΕ4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis

Hi everyone,I hope you're all well. I have this paper on my reading list. In case it's any help, I wrote a short summary of a previous but related article from the same research lab below. The author was a speaker at an online seminar series in the spring and summer and presented this earlier work. ...
by Fiver
Fri Sep 18, 2020 8:33 am
Forum: Science and Research
Topic: apoe2, while protective on its own, doesn't cancel out apoe4
Replies: 2
Views: 752

apoe2, while protective on its own, doesn't cancel out apoe4

New article in Nature: https://www.nature.com/articles/s41467-020-18198-x

Interesting....apoe2/4 had outcomes similar to apoe4/4, i.e. the 2, while protective on its own, can't cancel out the 4.
by Fiver
Sun Aug 30, 2020 4:10 pm
Forum: Our Stories
Topic: Anxious and fearful
Replies: 10
Views: 1435

Re: Anxious and fearful

Hi Chronophylos, you and I have some things in common. Similar ages, occupations, risk factors, and worries. As for your feelings about your apoe4 genes, it is totally natural to feel this way. I felt the same. Many of us did, or still do. It really is a roller coaster of a journey. In terms of the ...
by Fiver
Tue Aug 25, 2020 12:47 pm
Forum: Our Stories
Topic: Need some guidance
Replies: 5
Views: 758

Re: Need some guidance

Hi LC-FL, A few things come to mind, which might be helpful. PS - I'm not a doctor. Tincup is right about blood sugar control being something to look at, and it's something you can address now. If he recently retired maybe he is not as active and constantly training for work. Maye he can find someth...
by Fiver
Wed Aug 19, 2020 10:12 am
Forum: Science and Research
Topic: 4 drugs which may get approval in 3-5 years
Replies: 3
Views: 1264

Re: 4 drugs which may get approval in 3-5 years

very interesting and helpful! Thanks. I little bit of good news for my day. :)
by Fiver
Wed May 27, 2020 9:09 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 3946

Re: Alzheimer's Afternoons Seminar Series Summaries

Good question. I noticed some differences too. I don't know the specific answer for their studies but overall the researchers are using different models - usually mice, but often different strains - in different ways. The iPSC cells can be different, even different cell types. Sometimes the cells ar...
by Fiver
Wed May 27, 2020 9:03 am
Forum: Science and Research
Topic: APOE4 protective against melanoma
Replies: 1
Views: 588

Re: APOE4 protective against melanoma

Hi BrianR, I also saw this one: https://www.nature.com/articles/s41591-020-0879-3 Mice expressing the human APOE4 allele exhibited reduced melanoma progression and metastasis relative to APOE2 mice. APOE4 mice exhibited enhanced anti-tumor immune activation relative to APOE2 mice, and T cell depleti...
by Fiver
Fri May 15, 2020 7:54 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 3946

Re: Alzheimer's Afternoons Seminar Series Summaries

Dr. Elizabeth Head, Professor, University of California Irvine Alzheimer’s disease in Down syndrome: Link between Cerebrovascular pathology On Thursday, May 14, 2020 Dr. Liz Head presented her work on Alzheimer’s disease in Down Syndrome. Why would it be useful to study the pathology of AD that is a...
by Fiver
Thu May 14, 2020 3:40 pm
Forum: Prevention and Treatment
Topic: PREPRINT: Increased risk from COVI-19 in apoe4s
Replies: 10
Views: 2430

Re: PREPRINT: Increased risk from COVI-19 in apoe4s

Yep. I agree. I expected it too. Still, it seems like piling on.

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