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by Fiver
Thu Mar 12, 2020 6:59 pm
Forum: Prevention and Treatment
Topic: How to change size of lipid particles
Replies: 13
Views: 3154

Re: How to change size of lipid particles

What I know, there are *correlated* with greater HDL: niacin, statins, higher estrogen/lower testosterone patterns in females vs. males (up until menopause). This is from memory, I haven't red about this in a year or so.
by Fiver
Thu Mar 12, 2020 6:48 pm
Forum: Science and Research
Topic: Risks and benefits of apoe2 vs apoe4 in a 5,000-person neuropathological study
Replies: 2
Views: 843

Risks and benefits of apoe2 vs apoe4 in a 5,000-person neuropathological study

Hello everyone, I don't know if this has been posted before. I didn't see it when I checked. This table: https://www.nature.com/articles/s41467-019-14279-8/tables/2 From this recent study: https://www.nature.com/articles/s41467-019-14279-8 Really brought me down. I guess it's been a while since I re...
by Fiver
Fri Feb 28, 2020 10:34 am
Forum: Prevention and Treatment
Topic: Blue Cross Plans Say Alzheimer’s Has Tripled Among Adults Ages 30 To 64
Replies: 5
Views: 1441

Re: Blue Cross Plans Say Alzheimer’s Has Tripled Among Adults Ages 30 To 64

Hi. Thanks for sharing. The disconnect between the scale of the problem and the resistance to doing much of anything to reduce risk at the level of populations is disappointing. In our area we have horrible air pollution, mostly PM2, one of the older populations of any state, and high and increasing...
by Fiver
Tue Feb 11, 2020 6:50 am
Forum: Science and Research
Topic: 2019 review on APOE4 and AD
Replies: 1
Views: 583

Re: 2019 review on APOE4 and AD

I read this. Thanks for sharing! It's a good overview of the current apoe4 research. It might be worth linking somewhere for new folks. I wish they were further along on these approaches to addressing apoe4 directly.
by Fiver
Mon Feb 03, 2020 1:02 pm
Forum: Science and Research
Topic: Plant flavonols significantly reduce Alzheimer’s risk
Replies: 8
Views: 1490

Re: Plant flavonols significantly reduce Alzheimer’s risk

I love plant polyphenols and I'm not surprised that they reduce risk. They found reduced risk associated with kaempferol, myricetin, and isorhamnetin. They state they found not risk reduction associated with quercetin but their data kind of suggests that a larger study might detect that as well. I'm...
by Fiver
Sun Feb 02, 2020 12:31 pm
Forum: Science and Research
Topic: NIH grants Gladstone Institute $4.8M to study ApoE4
Replies: 2
Views: 656

Re: NIH grants Gladstone Institute $4.8M to study ApoE4

Years back I had high hopes for their apoe4 "structure correcters" That research hasn't seemed to move along as quickly as hoped. But I'm glad they're still at it!
by Fiver
Sun Feb 02, 2020 12:29 pm
Forum: Our Stories
Topic: Just discovered I'm 4/4, rocked.
Replies: 23
Views: 4112

Re: Just discovered I'm 4/4, rocked.

A similar experience here, though I am a bit older at 48. You've found the right place. Welcome to the group!
by Fiver
Thu Jan 16, 2020 6:46 am
Forum: Prevention and Treatment
Topic: Air pollution and apoe4 - bad to worse
Replies: 0
Views: 295

Air pollution and apoe4 - bad to worse

92% of people live in places where particulate matter pollution exceeds the World Health Organization’s guideline for healthy air. The gene variant, which ~25% of people possess, ApoE4 increases the risk that exposure to air pollution leads to #Alzheimers. https://nyti.ms/2TjBgpL Why Is Air Pollutio...
by Fiver
Wed Jan 15, 2020 12:08 pm
Forum: Prevention and Treatment
Topic: Zero carb diet will help prevent Alzheimer’s
Replies: 105
Views: 23121

Re: Zero carb diet will help prevent Alzheimer’s

Good point! Inflammation is important, and we can measure that. I actually did that, and saw inflammation go down at the time I made some changes. I hadn't thought of that in a while.
by Fiver
Mon Jan 13, 2020 7:47 am
Forum: Getting Started
Topic: Just got results, I carry 2 E4 genes, I have questions!
Replies: 5
Views: 1762

Re: Just got results, I carry 2 E4 genes, I have questions!

Hi. I'm not an expert or medical doctor. I just like reading about this. For what it is worth I'm not aware of any studies showing strong, direct links between apoe4 and these particular symptoms. But I can think of lots of indirect ways in which they could be related. So a search of the literature ...

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