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by Fiver
Sun Dec 29, 2019 12:00 pm
Forum: Prevention and Treatment
Topic: Sad NY Times story about a family dealing with AD and end-of-life care
Replies: 2
Views: 634

Sad NY Times story about a family dealing with AD and end-of-life care

This is a very sad story, absolutely no fun to read though it is beautifully written. I hesitated to share. But it makes a strong case for changes to our healthcare system and end-of-life policies. I'm glad the story was told. Sweethearts Forever. Then Came Alzheimer’s, Murder and Suicide. “They wer...
by Fiver
Tue Dec 10, 2019 12:10 pm
Forum: Prevention and Treatment
Topic: Failing to Dent LDL
Replies: 14
Views: 1371

Re: Failing to Dent LDL

Ah. I understand. I am fortunate to have a cardiologist friend who took an interest in my case. I'd be happy to ask about this the next time I see him - maybe get his thoughts on that chart.
by Fiver
Tue Dec 10, 2019 11:42 am
Forum: Prevention and Treatment
Topic: Failing to Dent LDL
Replies: 14
Views: 1371

Re: Failing to Dent LDL

I'd be very skeptical of that chart. Maybe get another opinion from a cardiologist, or better yet an expert on lipids. Some one you could talk about particle sizes, oxidation, apolipoprotein ratios, etc.
by Fiver
Mon Dec 09, 2019 7:30 am
Forum: Prevention and Treatment
Topic: Failing to Dent LDL
Replies: 14
Views: 1371

Re: Failing to Dent LDL

The lipid experts I talk with get excited about the new, strong statins and the new PCSK9 inhibitors because they can indeed get someone's LDL down near zero if they want to. And they can see good improvement in CVD symptoms, even to the point of not opting to use stents in some cases to significant...
by Fiver
Mon Dec 09, 2019 7:16 am
Forum: Science and Research
Topic: Mitochondrial Dysfunction in E4 carriers
Replies: 51
Views: 12513

Re: Mitochondrial Dysfunction in E4 carriers

Hi. Good questions! Maybe this could help: The mitochondria are indeed passed down from moms, except in very rare and extraordinary circumstances. But their circular chromosome is relatively small. Over the course of evolution many of the mitochondrial genes have been transferred from the mitochondr...
by Fiver
Mon Dec 02, 2019 10:16 am
Forum: Announcements and Events
Topic: Gene Therapy Trial for ApoE4 Homozygotes
Replies: 13
Views: 3831

Re: Gene Therapy Trial for ApoE4 Homozygotes

Talked with Denesey, who seems very nice. While they might be flexible on the age requirement they are focusing only on individuals with some diagnosed MCI. Makes sense. They want to be able to show improvement, if it occurs. But they are still looking for participants.
by Fiver
Mon Dec 02, 2019 9:54 am
Forum: Prevention and Treatment
Topic: Antioxidants which cross the BBB?
Replies: 3
Views: 609

Re: Antioxidants which cross the BBB?

Sulforaphane crosses the BBB and acts as an indirect anti-oxidant. It activates other natural anti-oxidant systems, lasting days compared to just hours for traditional anti-oxidants like vitamin C. So, that's another one.
by Fiver
Fri Nov 29, 2019 2:09 pm
Forum: Science and Research
Topic: AIr Pollution and E4s - not a good mix (more evidence)
Replies: 15
Views: 2466

Re: AIr Pollution and E4s - not a good mix (more evidence)

Yes. The evidence is strong and accumulating. Not just for AD but also other dementias and Parkinson's disease, not to mention the rock solid evidence it contributes to CVD. Unfortunately, the nation isn't doing much about it. In fact, PM2.5 pollution is up in recent years, after declining for almos...
by Fiver
Thu Nov 21, 2019 11:31 am
Forum: Prevention and Treatment
Topic: New Test Predicts Alzheimer’s Memory Loss Far in Advance
Replies: 4
Views: 767

Re: New Test Predicts Alzheimer’s Memory Loss Far in Advance

Thanks for sharing. I can see how this would be a huge help for research. And maybe we could know if our interventions are working. That would be good. But I have to admit my first thought was: this is terrifying. How would things change - insurance, job clearances, etc. - to have this on a medical ...
by Fiver
Thu Nov 14, 2019 8:37 am
Forum: Announcements and Events
Topic: New Wiki - Mitochondria
Replies: 10
Views: 1503

Re: New Wiki - Mitochondria

Wow! What a great resource. Thanks for taking this on!

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