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by Fiver
Mon Dec 09, 2019 7:16 am
Forum: Science and Research
Topic: Mitochondrial Dysfunction in E4 carriers
Replies: 51
Views: 16156

Re: Mitochondrial Dysfunction in E4 carriers

Hi. Good questions! Maybe this could help: The mitochondria are indeed passed down from moms, except in very rare and extraordinary circumstances. But their circular chromosome is relatively small. Over the course of evolution many of the mitochondrial genes have been transferred from the mitochondr...
by Fiver
Mon Dec 02, 2019 10:16 am
Forum: Announcements and Events
Topic: Gene Therapy Trial for ApoE4 Homozygotes
Replies: 13
Views: 5212

Re: Gene Therapy Trial for ApoE4 Homozygotes

Talked with Denesey, who seems very nice. While they might be flexible on the age requirement they are focusing only on individuals with some diagnosed MCI. Makes sense. They want to be able to show improvement, if it occurs. But they are still looking for participants.
by Fiver
Mon Dec 02, 2019 9:54 am
Forum: Prevention and Treatment
Topic: Antioxidants which cross the BBB?
Replies: 3
Views: 927

Re: Antioxidants which cross the BBB?

Sulforaphane crosses the BBB and acts as an indirect anti-oxidant. It activates other natural anti-oxidant systems, lasting days compared to just hours for traditional anti-oxidants like vitamin C. So, that's another one.
by Fiver
Fri Nov 29, 2019 2:09 pm
Forum: Science and Research
Topic: AIr Pollution and E4s - not a good mix (more evidence)
Replies: 15
Views: 3453

Re: AIr Pollution and E4s - not a good mix (more evidence)

Yes. The evidence is strong and accumulating. Not just for AD but also other dementias and Parkinson's disease, not to mention the rock solid evidence it contributes to CVD. Unfortunately, the nation isn't doing much about it. In fact, PM2.5 pollution is up in recent years, after declining for almos...
by Fiver
Thu Nov 21, 2019 11:31 am
Forum: Prevention and Treatment
Topic: New Test Predicts Alzheimer’s Memory Loss Far in Advance
Replies: 4
Views: 1159

Re: New Test Predicts Alzheimer’s Memory Loss Far in Advance

Thanks for sharing. I can see how this would be a huge help for research. And maybe we could know if our interventions are working. That would be good. But I have to admit my first thought was: this is terrifying. How would things change - insurance, job clearances, etc. - to have this on a medical ...
by Fiver
Thu Nov 14, 2019 8:37 am
Forum: Announcements and Events
Topic: New Wiki - Mitochondria
Replies: 10
Views: 2751

Re: New Wiki - Mitochondria

Wow! What a great resource. Thanks for taking this on!
by Fiver
Wed Nov 13, 2019 7:04 am
Forum: Announcements and Events
Topic: Fitness and Dementia Study
Replies: 7
Views: 2350

Re: Fitness and Dementia Study

It's so nice to see the Hazard Ratios going in the "good" direction. Thanks for sharing. Off to the gym.
by Fiver
Mon Nov 04, 2019 5:17 pm
Forum: Prevention and Treatment
Topic: New Alzheimer's Drug?
Replies: 2
Views: 810

Re: New Alzheimer's Drug?

Read this too. While I love that this is a natural product from a seaweed, I am not getting my hopes up too high. The strategy is to use the seaweed compound to modify the gut flora to prevent leaky gut and inflammation of the brain. Seems early in the discovery process, and China is speeding up the...
by Fiver
Mon Nov 04, 2019 5:13 pm
Forum: Science and Research
Topic: Genetic Mutation of ApoE protects against AD
Replies: 8
Views: 1650

Re: Genetic Mutation of ApoE protects against AD

Saw this too. This seems like a really important clue!

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