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by Fiver
Fri Oct 25, 2019 8:49 am
Forum: Announcements and Events
Topic: Gene Therapy Trial for ApoE4 Homozygotes
Replies: 13
Views: 5644

Re: Gene Therapy Trial for ApoE4 Homozygotes

Hi Julie and BettyLacy. Thanks. I'd been following this. At one point I saw that there was an age range criteria. I wondering if that's been dropped or expanded?
by Fiver
Wed Oct 23, 2019 7:44 am
Forum: Our Stories
Topic: Ready to Quit
Replies: 48
Views: 10036

Re: Ready to Quit

Hi Jan18. I understand. It's gets to be overwhelming. We keep pushing and pushing, in part because we don't know if we are doing enough. Remember, there is good evidence that we don't have to get it all 100% right, all the time. The lifestyle studies that show reduced risk used broad categories whic...
by Fiver
Wed Oct 16, 2019 7:44 am
Forum: Prevention and Treatment
Topic: Review article on AD risk factors: so many studies, so many conflicting or inconclusive results
Replies: 5
Views: 1644

Re: Review article on AD risk factors: so many studies, so many conflicting or inconclusive results

Yes, it's frustrating. Incomplete data about what works, for who, and at what ages. Few practical ways to monitor our status to know if our efforts are working. And unnecessary challenges for arranging long-term care and making end-of-life decisions. I agree. But we can address these issues by aggre...
by Fiver
Fri Oct 11, 2019 11:11 am
Forum: Prevention and Treatment
Topic: Risk Factor Question - Family History
Replies: 6
Views: 1600

Re: Risk Factor Question - Family History

That is my understanding also. Not great for me, but good for you!
by Fiver
Fri Oct 11, 2019 7:02 am
Forum: Prevention and Treatment
Topic: U.S. surgeons general: Dementia is our top public health crisis | Commentary
Replies: 3
Views: 705

Re: U.S. surgeons general: Dementia is our top public health crisis | Commentary

I agree! From talking with doctors in my area it seems like they need a pre-packaged screening program to order for patients, where they get a report with recommendations. Maybe a set of blood tests, a questionare, and a cognitive test where a program scores them and generates a report. And recommen...
by Fiver
Thu Oct 10, 2019 9:29 am
Forum: Prevention and Treatment
Topic: U.S. surgeons general: Dementia is our top public health crisis | Commentary
Replies: 3
Views: 705

U.S. surgeons general: Dementia is our top public health crisis | Commentary

Today's article from past US Surgeons General: https://www.orlandosentinel.com/opinion/guest-commentary/os-op-dementia-crisis-surgeons-general-20191010-xrunvqs4tbhavfjqdkcsvxvn3u-story.html Despite these staggering numbers, dementia remains little understood — when it’s not misunderstood — and garne...
by Fiver
Mon Sep 30, 2019 7:47 am
Forum: Prevention and Treatment
Topic: Epigenetics - can we really turn APOE4 off?
Replies: 30
Views: 6948

Re: Epigenetics - can we really turn APOE4 off?

In terms of how expression of the apoe4 gene could be manipulated the options would be indirect (changing methylation of nearby DNA or acetylation of nearby histones, small RNA which are poorly understood) or direct (anti-sense DNA silencing, RNA destruction, protein destruction). But it's still not...
by Fiver
Wed Sep 25, 2019 7:01 am
Forum: Science and Research
Topic: Clusterin / ApoJ
Replies: 2
Views: 909

Re: Clusterin / ApoJ

Thanks for sharing this! I won't get to read it until things settle down here, but I am interested.
by Fiver
Wed Sep 18, 2019 1:46 pm
Forum: Science and Research
Topic: Epigenetic signatures of methylated DNA cytosine in Alzheimer’s disease
Replies: 6
Views: 1320

Re: Epigenetic signatures of methylated DNA cytosine in Alzheimer’s disease

I'd like to think that too! I am a big fan of plant polyphenols. I'd love it if they were a part of the solution. I think it's going to take some time before we know for certain if we can alter methylation in a useful way with lifestyle. These techniques are pretty cutting-edge. I'm not aware that t...
by Fiver
Wed Sep 18, 2019 7:43 am
Forum: Science and Research
Topic: Epigenetic signatures of methylated DNA cytosine in Alzheimer’s disease
Replies: 6
Views: 1320

Re: Epigenetic signatures of methylated DNA cytosine in Alzheimer’s disease

Wow. That's a very interesting and VERY dense paper! I think I could spend all week reading this one to really understand it. Basically, the researchers looked at cells with genes known to trigger early onset AD and other cells with the apoe4 genes contributing to late onset AD, comparing them to v...

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