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by Tincup
Tue Apr 28, 2020 1:30 pm
Forum: The Social Hour
Topic: Genetic Risk Factor for Covid-19
Replies: 15
Views: 1315

Re: Genetic Risk Factor for Covid-19

I found rs2070788 in my Promethease report. I pasted the string in the search window at the top and hit return. Nothing happened. I deleted the last character and the allele showed up. I'm TT. I reran my 23andme report (on my original dna sample) late last year then ran that new report through Prom...
by Tincup
Sun Apr 26, 2020 12:18 pm
Forum: The Social Hour
Topic: Genetic Risk Factor for Covid-19
Replies: 15
Views: 1315

Re: Genetic Risk Factor for Covid-19

Ooohhh - Let me know if it's useful as I got that email as well but as I'd already got the information I needed I didn't explore any further. Sometimes I think I can know too much!! Note, when uncompressed they all have a file extension of .vcf. This extension is also used for contacts in an addres...
by Tincup
Sun Apr 26, 2020 6:19 am
Forum: The Social Hour
Topic: Genetic Risk Factor for Covid-19
Replies: 15
Views: 1315

Re: Genetic Risk Factor for Covid-19

Weird - seems Promethease didn't genotype the rs2070788 variant for you so I have no idea how Nutrahacker managed to come back with a result...? I got this email from Nutrahacker - maybe imputed??? I downloaded the 395 MB file, which has like ~20 compressed files. I've not explored, yet... Hey ther...
by Tincup
Sat Apr 25, 2020 3:17 pm
Forum: The Social Hour
Topic: Genetic Risk Factor for Covid-19
Replies: 15
Views: 1315

Re: Genetic Risk Factor for Covid-19

GemmaJ wrote: Maybe search Promethease for TMPRSS2?

This is what I get when I do that: rs12329760(C;T)
by Tincup
Sat Apr 25, 2020 12:29 pm
Forum: The Social Hour
Topic: Genetic Risk Factor for Covid-19
Replies: 15
Views: 1315

Re: Genetic Risk Factor for Covid-19

So I did it. Interestingly the report shows rs2070788 as AG while a search of the raw .txt file or my Promethease report for rs2070788 comes up empty. So I wonder where their report gets the AG?
by Tincup
Wed Apr 22, 2020 1:06 pm
Forum: Prevention and Treatment
Topic: The Ketogenic Diet: A Neurologist’s Warning
Replies: 50
Views: 5944

Re: The Ketogenic Diet: A Neurologist’s Warning

Interesting, Tincup! Sounds like you are a pro at managing your Afib and doing your testings. After a 2.5 month afib episode within the first 4 months, I figured out how to keep it mostly at bay and got the approval of my EP. My path to afib was chronic fitness - likely 15% of those with afib. Most...
by Tincup
Wed Apr 22, 2020 12:03 pm
Forum: Science and Research
Topic: How do specificity and sensitivity work with lab testing?
Replies: 8
Views: 407

Re: How do specificity and sensitivity work with lab testing?

One thing to note, with a 1% prevalence, if you test false, the probability that you've not had the bug is very near 100%. In my 1 million case example. There are only 100 false negatives out of nearly 1 million.
by Tincup
Wed Apr 22, 2020 9:36 am
Forum: Science and Research
Topic: How do specificity and sensitivity work with lab testing?
Replies: 8
Views: 407

Re: How do specificity and sensitivity work with lab testing?

Thanks, Tincup. I know you're smart and you get this stuff, so I trust what you've done here. As Slacker says, it all depends on prevalence (or assumed prevalence). In my example, I assumed 1% actually had the disease, so 50/50. If you assume 25% actually have it, then false positives are ~3% and 1...
by Tincup
Wed Apr 22, 2020 7:48 am
Forum: Prevention and Treatment
Topic: The Ketogenic Diet: A Neurologist’s Warning
Replies: 50
Views: 5944

Re: The Ketogenic Diet: A Neurologist’s Warning

On the topic of the oximeter, have you seen this? "There is a way we could identify more patients who have Covid pneumonia sooner and treat them more effectively — and it would not require waiting for a coronavirus test at a hospital or doctor’s office. It requires detecting silent hypoxia ear...
by Tincup
Wed Apr 22, 2020 7:36 am
Forum: Science and Research
Topic: How do specificity and sensitivity work with lab testing?
Replies: 8
Views: 407

Re: How do specificity and sensitivity work with lab testing?

Asked about L.A. County study’s findings, Dr. Birx warned reporters on Monday, “These [antibodies] tests are not 100 percent sensitive or specific,” adding: If you have one percent of your population infected and you have a test that’s only 99 percent specific that means that when you find a positi...

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