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by RichardS
Fri Feb 05, 2016 1:16 pm
Forum: Our Stories
Topic: Any way to find out more about my Dad's diagnosis? Is it worth trying?
Replies: 7
Views: 1252

Re: Any way to find out more about my Dad's diagnosis? Is it worth trying?

I lost my dad to AD 2 1/2 years ago and remember thinking about this issue, as well. I don't think at this point that tracking down his apoe status is the top priority. If anything, I would want to focus on vascular risk factors like high blood pressure, diagnosed or suspected strokes, transient isc...
by RichardS
Fri Feb 05, 2016 1:03 pm
Forum: Our Stories
Topic: Diet pre colonoscopy
Replies: 18
Views: 3542

Re: Diet pre colonoscopy

I had the colonoscopy last year to celebrate my 50th. It was while I was still doing a 60%+ fat diet and found fasting relatively easy, so I just did not each much during the prep-diet period. FWIW, I was worried about what the procedure would do to my gut flora. Within a day, my bathroom "habi...
by RichardS
Fri Jan 22, 2016 6:43 pm
Forum: Announcements and Events
Topic: Dr. Bredesen's new company
Replies: 28
Views: 6450

Re: Dr. Bredesen's new company

Great news! Looking forward to hearing about the developments.
by RichardS
Fri Jan 22, 2016 6:38 pm
Forum: Prevention and Treatment
Topic: Hopefully this open data initiative will help AD research ...
Replies: 4
Views: 1186

Re: Hopefully this open data initiative will help AD research ...

Definitely something to watch. I've been involved with a multi-center research program for a long time that pays very close attention to patent stuff. I like the open science initiative and really hope to see examples like this succeed so that other institutions will feel confident about doing the s...
by RichardS
Fri Jan 22, 2016 6:27 pm
Forum: Prevention and Treatment
Topic: Could Nicotine be protective?
Replies: 4
Views: 1405

Re: Could Nicotine be protective?

I am similarly skeptical of nicotine for AD. It was being investigated back in the late 80's when I started in neuropsychology. Nothing much has changes as best I can tell. Tacrine, the first approved drug for treatment of AD and cholinergic agonist (as is nicotine), had a minuscule if any clinical ...
by RichardS
Thu Jan 21, 2016 8:55 am
Forum: Science and Research
Topic: A new role for ApoE explains its diverse range of effects, particularly in Alzheimer's
Replies: 18
Views: 3814

Re: A new role for ApoE explains its diverse range of effects, particularly in Alzheimer's

Dr. Mahley weighs in on the new E4 evidence below. It appears to have moved understanding of APOE-ε4 tremendously. I'd love to see full-text if anyone has access- both for the article AND for the comments. Apparently lots of heavy hitters are chiming in... http://www.the-scientist.com/?articles.vie...
by RichardS
Tue Jan 19, 2016 9:26 pm
Forum: Our Stories
Topic: Cognitive testing results before and after 5 months of the MEND Therapy
Replies: 19
Views: 2640

Re: Cognitive testing results before and after 5 months of the MEND Therapy

Circ wrote: I wanted to mention that once I heard or read that people with good cognitive reserve will often acquire LOAD later than they otherwise might have (that part of course being uncertain), but they will decline faster. By the time they show symptoms they've gone through their reserve for th...
by RichardS
Fri Jan 15, 2016 4:00 pm
Forum: Our Stories
Topic: Cognitive testing results before and after 5 months of the MEND Therapy
Replies: 19
Views: 2640

Re: Cognitive testing results before and after 5 months of the MEND Therapy

It’s clear from the results of my first assessment that I was, indeed, hitting the incorrect key (and the application did not capture my input). The verbal test showed that I remembered none of the words at the beginning of the assessment, though I recalled 14 of the 15 words at the end of it. I ca...
by RichardS
Fri Jan 08, 2016 12:53 pm
Forum: Prevention and Treatment
Topic: FYI unfiltered coffee and ldl
Replies: 20
Views: 3723

Re: FYI unfiltered coffee and ldl

I'm wondering if cafestol is really such a bad player. This seems to be a small effect on LDL. A 5-cup a day intake to get a 6-8% rise in LDL. I think the average coffee consumer has more like 2-3 cups a day, but I don't remember where I saw that statistic. Also, at least in controlled trial http://...
by RichardS
Mon Dec 28, 2015 6:42 pm
Forum: Prevention and Treatment
Topic: New Blood test- 96% accurate
Replies: 2
Views: 997

Re: New Blood test- 96% accurate

The original UNT link did not work for me. This should work: http://www.untsystem.edu/news/2015/November/15-11-9_UNTHSC-Blood-test-detects-pre-Alzheimer%E2%80%99s-in-Mexican-Americans-with-96-percent-accuracy.htm Blood test detects pre-Alzheimer’s in Mexican-Americans with 96 percent accuracy Andrew...

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