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by frankiesfriend
Fri Jul 19, 2019 3:53 pm
Forum: Science and Research
Topic: New article on exercise released this week
Replies: 2
Views: 555

Re: New article on exercise released this week

This impressive research hints at the mechanisms by which physical activity protects the aging brain. "Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline" Nicole C. Berchtold a,*, G. Aleph Prieto a, Michael Phelan b,...
by frankiesfriend
Tue Jul 02, 2019 5:35 pm
Forum: Science and Research
Topic: Sleep as a potential biomarker of tau and β-amyloid burden in the human brain
Replies: 6
Views: 1324

Re: Sleep as a potential biomarker of tau and β-amyloid burden in the human brain

In a typical polysomnography used to evaluate sleep apnea or other sleep disorders, do they look at spindle coupling and amplitude which is indicated in this paper to correlate to tau and amyloid accumulation? I am interested in obtaining a sleep study due to a recent history (five years) of poor sl...
by frankiesfriend
Mon Jul 01, 2019 7:10 am
Forum: Science and Research
Topic: More info on why APOe4 may be worse for women-And what you can do about it.
Replies: 2
Views: 692

Re: More info on why APOe4 may be worse for women-And what you can do about it.

Is there any evidence that tau accumulation is reversed by lifestyle changes embodied in RECODE, or are the improvments observed in early AD by following the Bredesen protocol compensatory to a fixed pathology?
by frankiesfriend
Tue Jun 25, 2019 5:27 pm
Forum: Our Stories
Topic: New this year - intro and question
Replies: 1
Views: 527

New this year - intro and question

Last winter I was happy to find this web group and discover the wealth of information offered herein. Like many others, I have concerns about my risk of developing AD, having watched my mother’s struggles with her ever increasing confusion, anxiety and loss of autonomy leading up to her death at age...
by frankiesfriend
Sun Mar 10, 2019 10:08 am
Forum: Our Stories
Topic: DISAPPOINTING RESULTS
Replies: 20
Views: 3759

Re: DISAPPOINTING RESULTS

Hi Roxanne, The low weight, high energy, sleeplessness, anxiety and increased blood pressure, as well as increased cholesterol, were all symptoms I experienced one year when I was hyperthyroid (too much thyroid hormone) - probably induced by stress. If you were taking T3, then you probably were unde...
by frankiesfriend
Tue Feb 26, 2019 5:04 pm
Forum: Prevention and Treatment
Topic: glucose meter accuracy
Replies: 1
Views: 412

glucose meter accuracy

Recently we ordered new test strips for my husband's blood glucose meter. I periodically also check my fasting blood sugar, and noted a lower-than-usual reading with a new test strip. I had one test strip left from the old batch, and found that side-by-side testing of the new strip vs. the old using...
by frankiesfriend
Fri Feb 22, 2019 5:46 pm
Forum: Science and Research
Topic: Cholesterol level sweet spot
Replies: 2
Views: 728

Cholesterol level sweet spot

Serum Cholesterol and Incident Alzheimer's Disease Findings From the Adult Changes in Thought Study Markham, et al. J. of the American Geriatric Society, 2018;66(12):2344-2352. This study indicates that what might be considered modestly raised non-HDL cholesterol is associated with the lowest incide...
by frankiesfriend
Sat Feb 09, 2019 4:22 pm
Forum: Science and Research
Topic: Why We Sleep, Matthew Walker
Replies: 6
Views: 1255

Re: Why We Sleep, Matthew Walker

After reading this book, I added black-out shades to the bedroom windows and turned down the thermostat five degrees before bed. I also removed the clock from the bedroom in an effort not to stir up more concern about how many hours and minutes I have slept. These two articles may be of interest...i...
by frankiesfriend
Thu Feb 07, 2019 5:44 am
Forum: Prevention and Treatment
Topic: Full Keto diet or not?
Replies: 28
Views: 4788

Re: Full Keto diet or not?

You may be interested in a discussion with Nir Barzilai, who carried out a small study of centenarians with a succinct gene pool, in which he noted healthy aging despite life style and APOE status. You may have won the genetic jackpot if your parents are both long-lived and aging with relatively goo...
by frankiesfriend
Fri Feb 01, 2019 7:48 am
Forum: Prevention and Treatment
Topic: Low AD even with AD neuropathologies
Replies: 0
Views: 316

Low AD even with AD neuropathologies

“Physical Activity, Common Brain Pathologies, and Cognition in Community-dwelling older adults” - Neurology, January 16, 2019, Aron Buchman – Rush Memory Aging Project. Using accelerometers, these researchers measured all physical activity (all movement…not just exercise), and found better neurocogn...

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