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by circular
Thu Jan 30, 2014 4:15 pm
Forum: Prevention and Treatment
Topic: Hormone Replacement Therapy E4 Women
Replies: 717
Views: 147090

Re: Hormone Replacement Therapy E4 Women

Unfortunately the problem is there's no clear advise on how long you can take it and what happens when it's stopped. We're all kind of wishing for something cut and dry, but studies are usually murky. Your anecdote is very interesting, although of course it doesn't indicate stopping HRT was the caus...
by circular
Thu Jan 30, 2014 2:55 pm
Forum: Prevention and Treatment
Topic: Hormone Replacement Therapy E4 Women
Replies: 717
Views: 147090

Re: Hormone Replacement Therapy E4 Women

Hi, I'm not sure that last link helps much, since they just compared no use with any use, presumably use with all combinations of duration and starting age vis menopause age, and didn't study ApoE4. At the end they say "We discuss trends in hormone therapy research that could explain our novel ...
by circular
Thu Jan 30, 2014 2:28 pm
Forum: Prevention and Treatment
Topic: EDS/Connective Tissue Disorder & Alzheimer's
Replies: 9
Views: 2209

Re: EDS/Connective Tissue Disorder & Alzheimer's

I'm so sorry. This is really a crappy odessy to have to be on at any age, but at least I can remember a lot of years that were *relatively* normal. Kids with illnesses are sometimes more resilient than adults, unfortunately becoming wiser than their years in order to keep from being any more trouble...
by circular
Thu Jan 30, 2014 2:18 pm
Forum: Prevention and Treatment
Topic: Trouble Swallowing (Dysphagia) and ApoE4
Replies: 4
Views: 1562

Re: Trouble Swallowing (Dysphagia) and ApoE4

I also thought, and still think it could be, the autonomic end. Who knows. Or E4 is messing with our autonomic systems too? http://books.google.com/books?id=c1tL8C9ryMQC&lpg=PA178&ots=Ki_WaqzjH5&dq=apoe4%20autonomic%20neurons&pg=PA178#v=onepage&q=apoe4%20autonomic%20neurons&f...
by circular
Thu Jan 30, 2014 12:10 pm
Forum: Prevention and Treatment
Topic: EDS/Connective Tissue Disorder & Alzheimer's
Replies: 9
Views: 2209

Re: EDS/Connective Tissue Disorder & Alzheimer's

JulieGee! I meant to ask how your nephews surgeries went!?
by circular
Thu Jan 30, 2014 12:10 pm
Forum: Prevention and Treatment
Topic: EDS/Connective Tissue Disorder & Alzheimer's
Replies: 9
Views: 2209

Re: EDS/Connective Tissue Disorder & Alzheimer's

Just found this thread. I was dx joint hypermobility syndrome, which of course is really hypermobile EDS but "mild". I am sure my mother has it - loads of osteoarthritis and now RA, hypermobile that I can see in her family going back several generations, her mother and aunt had AD, brother...
by circular
Thu Jan 30, 2014 12:06 pm
Forum: Prevention and Treatment
Topic: Trouble Swallowing (Dysphagia) and ApoE4
Replies: 4
Views: 1562

Trouble Swallowing (Dysphagia) and ApoE4

Good grief, this appears to need more study, but I developed mild trouble swallowing in the last several years. Very mild and only noticeable on occasion.

http://gut.bmj.com/content/61/Suppl_2/A322.1
by circular
Thu Jan 30, 2014 11:10 am
Forum: Prevention and Treatment
Topic: Hormone Replacement Therapy E4 Women
Replies: 717
Views: 147090

Re: Hormone Replacement Therapy E4 Women

Okay gals, this just in from my NEJM Journal Watch email. Noteworthy is the usual lack of ApoE info and that these are estradiol levels of women *not* on HRT, so they are not equine estrogen. "High (and Low?) Endogenous Estradiol Linked to Increased Dementia Risk in Postmenopausal Women By Amy ...
by circular
Wed Jan 29, 2014 5:16 pm
Forum: Prevention and Treatment
Topic: Greek Coffee
Replies: 8
Views: 2004

Re: Greek Coffee

...having studied populations of the long-lived for nearly a decade Have you found any populations with a high ApoE4 prevalence that are long-lived? The best I could find was a village in England called Montecute. http://www.alongerhealthylife.com/longevity-village/montacute-england-longevity-hotsp...
by circular
Wed Jan 29, 2014 2:36 pm
Forum: Prevention and Treatment
Topic: Greek Coffee
Replies: 8
Views: 2004

Re: Greek Coffee

Mediterraneans have it good, Ikarian males even better? (Article states longest lived women are in Okinawa - maybe a fermented soy thing going on there?) "The project grew out of studies by my partners, Dr. Gianni Pes of the University of Sassari in Italy and Dr. Michel Poulain, a Belgian demog...

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