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by DanH44
Tue Sep 10, 2019 2:33 pm
Forum: Our Stories
Topic: Addendum to Two month N=1 experiment: 250 mg NMN + 50 mg pterostilbene
Replies: 0
Views: 120

Addendum to Two month N=1 experiment: 250 mg NMN + 50 mg pterostilbene

... lecithin is from this podcast with Chris Masterhjohn: https://peterattiamd.com/chrismasterjohn/ [1:50:00]. Basically Chris says that if you have MTHFR problems (I'm homo for C677T), taking massive B3 (ie NMN) will further stress your methylation inadequacies. Since the choline cycle can prop ...
by Hboroughs
Mon Sep 02, 2019 8:07 am
Forum: Prevention and Treatment
Topic: Resveratrol and Estrogen Therapy
Replies: 12
Views: 645

Re: Resveratrol and Estrogen Therapy

... Genes"? He has a huge section on COMT and it is so well written and researched. He also covers some other common genetic SNPs (especially MTHFR). It is fascinating and I highly recommend it. One very interesting aspect of the book is his focus on genes that may not have been "born" ...
by Hboroughs
Thu Aug 29, 2019 11:34 am
Forum: Prevention and Treatment
Topic: Creatine increase in PCC in early AD
Replies: 5
Views: 329

Re: Creatine increase in PCC in early AD

Creatine is often recommended for those with MTHFR defects as it is a large user of methyl donors. In this way supplementation preserves methyl groups for other uses. I have tried it with the result being wicked insomnia. Choline supplementation ...
by xactly
Sun Aug 11, 2019 7:38 am
Forum: Prevention and Treatment
Topic: Qs re: homocysteine-lowering vitamins
Replies: 37
Views: 5862

Re: Qs re: homocysteine-lowering vitamins

Roel wrote:
xactly wrote:Do you know what your results are for the MTHFR C677T SNP are? (It's at rs1801133.)

rs1801133 1 11856378 GG

Looks like you also have the wild type (aka normal) for MTHFR C677T. That's great!
by Roel
Fri Aug 09, 2019 9:45 pm
Forum: Prevention and Treatment
Topic: Qs re: homocysteine-lowering vitamins
Replies: 37
Views: 5862

Re: Qs re: homocysteine-lowering vitamins

Thank you very much for the input.

xactly wrote:Do you know what your results are for the MTHFR C677T SNP are? (It's at rs1801133.)

rs1801133 1 11856378 GG

On the homocysteine, from memory, Vit B2 is good for lowering it.
by xactly
Mon Aug 05, 2019 6:37 pm
Forum: Prevention and Treatment
Topic: Qs re: homocysteine-lowering vitamins
Replies: 37
Views: 5862

Re: Qs re: homocysteine-lowering vitamins

... and AD), it's a good idea to test your homocysteine and implement a dietary protocol to lower it. Do you know what your results are for the MTHFR C677T SNP are? (It's at rs1801133.) That's the main SNP that affects the methylation cycle. If you have the wild type at that position (C/C), ...
by IForgot
Fri Aug 02, 2019 2:34 pm
Forum: Getting Started
Topic: Still new and digesting 4/4>>> questions
Replies: 9
Views: 606

Still new and digesting 4/4>>> questions

... cognitive health, https://www.alzdiscovery.org/cognitive-vitality ; More info on diet, research and explanations, https://www.geneticlifehacks.com/mthfr/ . Be strong and carry on.... Steven
by IForgot
Wed Jul 31, 2019 6:35 pm
Forum: Getting Started
Topic: Newbie with a basic gene question
Replies: 6
Views: 404

Re: Newbie with a basic gene question

... long winded intro, now onto the question; From the excellent Wiki write up on Methylation; "Two of the most common genetic polymorphisms of MTHFR are C677T (rs1801133, T is the risk allele) and A1298C (rs1801131, C is the risk allele)." However, deep diving my 23andme raw data, I find ...
by NF52
Tue Jul 30, 2019 6:43 pm
Forum: Getting Started
Topic: Newbie with a basic gene question
Replies: 6
Views: 404

Re: Newbie with a basic gene question

Hello all, ...From the excellent Wiki write up on Methylation; "Two of the most common genetic polymorphisms of MTHFR are C677T (rs1801133, T is the risk allele) and A1298C (rs1801131, C is the risk allele)." However, deep diving my 23andme raw data, I find marker SNP rs1801131 ...
by Davida
Tue Jul 30, 2019 5:55 pm
Forum: Getting Started
Topic: Newbie with a basic gene question
Replies: 6
Views: 404

Re: Newbie with a basic gene question

... long winded intro, now onto the question; From the excellent Wiki write up on Methylation; "Two of the most common genetic polymorphisms of MTHFR are C677T (rs1801133, T is the risk allele) and A1298C (rs1801131, C is the risk allele)." However, deep diving my 23andme raw data, I find ...

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