Search found 636 matches
- Wed Jan 27, 2021 7:56 am
- Forum: Science and Research
- Topic: Summary of Massachusetts General Hospital’s Multicultural Alzheimer’s Prevention Program ApoE Symposium
- Replies: 4
- Views: 1852
Re: Summary of Massachusetts General Hospital’s Multicultural Alzheimer’s Prevention Program ApoE Symposium
Yes, DAG is common and does a lot of different things. As far as I could tell from the seminars, the key take away was that e4 shifts the profile of lipid types in cells - some were reduced, others were increased. So many possible consequences - from changes in membrane fluidity, inflammation, enzym...
- Tue Jan 26, 2021 8:03 am
- Forum: Science and Research
- Topic: Summary of Massachusetts General Hospital’s Multicultural Alzheimer’s Prevention Program ApoE Symposium
- Replies: 4
- Views: 1852
Re: Summary of Massachusetts General Hospital’s Multicultural Alzheimer’s Prevention Program ApoE Symposium
Hi Chris. Debio-025, believe. First I'd heard of it.
- Mon Jan 25, 2021 12:19 pm
- Forum: Science and Research
- Topic: Summary of Massachusetts General Hospital’s Multicultural Alzheimer’s Prevention Program ApoE Symposium
- Replies: 4
- Views: 1852
Summary of Massachusetts General Hospital’s Multicultural Alzheimer’s Prevention Program ApoE Symposium
Something I wrote after attending a recent symposium on apoe4. It lost some of the formatting in the transfer but sharing in case anyone is interested. I hope everyone is doing well - staying healthy and warm. On Friday approximately two hundred scientists from around the world met virtually to sha...
- Wed Jan 06, 2021 10:45 am
- Forum: Getting Started
- Topic: STATINs
- Replies: 5
- Views: 2772
Re: STATINs
From my experience I totally agree with the usefulness of the coronary calcium score. I think we'll see this become even more common and accessible in the near future. It was such a relief to get my score. And unusual - how many accurate tests are there we can count on currently? Just one minor thin...
- Mon Oct 26, 2020 6:09 am
- Forum: Science and Research
- Topic: APOΕ4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis
- Replies: 26
- Views: 8960
Re: APOΕ4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis
Hi everyone,I hope you're all well. I have this paper on my reading list. In case it's any help, I wrote a short summary of a previous but related article from the same research lab below. The author was a speaker at an online seminar series in the spring and summer and presented this earlier work. ...
- Fri Sep 18, 2020 8:33 am
- Forum: Science and Research
- Topic: apoe2, while protective on its own, doesn't cancel out apoe4
- Replies: 2
- Views: 1701
apoe2, while protective on its own, doesn't cancel out apoe4
New article in Nature: https://www.nature.com/articles/s41467-020-18198-x
Interesting....apoe2/4 had outcomes similar to apoe4/4, i.e. the 2, while protective on its own, can't cancel out the 4.
Interesting....apoe2/4 had outcomes similar to apoe4/4, i.e. the 2, while protective on its own, can't cancel out the 4.
- Sun Aug 30, 2020 4:10 pm
- Forum: Our Stories
- Topic: Anxious and fearful
- Replies: 10
- Views: 4010
Re: Anxious and fearful
Hi Chronophylos, you and I have some things in common. Similar ages, occupations, risk factors, and worries. As for your feelings about your apoe4 genes, it is totally natural to feel this way. I felt the same. Many of us did, or still do. It really is a roller coaster of a journey. In terms of the ...
- Tue Aug 25, 2020 12:47 pm
- Forum: Our Stories
- Topic: Need some guidance
- Replies: 5
- Views: 2282
Re: Need some guidance
Hi LC-FL, A few things come to mind, which might be helpful. PS - I'm not a doctor. Tincup is right about blood sugar control being something to look at, and it's something you can address now. If he recently retired maybe he is not as active and constantly training for work. Maye he can find someth...
- Wed Aug 19, 2020 10:12 am
- Forum: Science and Research
- Topic: 4 drugs which may get approval in 3-5 years
- Replies: 3
- Views: 2676
Re: 4 drugs which may get approval in 3-5 years
very interesting and helpful! Thanks. I little bit of good news for my day.
- Wed May 27, 2020 9:09 am
- Forum: Science and Research
- Topic: Alzheimer's Afternoons Seminar Series Summaries
- Replies: 20
- Views: 8730
Re: Alzheimer's Afternoons Seminar Series Summaries
Good question. I noticed some differences too. I don't know the specific answer for their studies but overall the researchers are using different models - usually mice, but often different strains - in different ways. The iPSC cells can be different, even different cell types. Sometimes the cells ar...