Search found 396 matches

by ApropoE4
Sat May 15, 2021 3:41 pm
Forum: The Social Hour
Topic: Free speech
Replies: 13
Views: 8734

Re: Free speech

Mercola is one of the top sources of medical disinformation. He is first on a recent list of the top sources of anti vax "information". By spreading disinformation he's causing hundreds of thousands of needless deaths and he should absolutely be silenced. https://252f2edd-1c8b-49f5-9bb2-cb...
by ApropoE4
Sat May 01, 2021 2:37 pm
Forum: Announcements and Events
Topic: Gene Therapy Trial for ApoE4 Homozygotes
Replies: 49
Views: 37662

Re: Gene Therapy Trial for ApoE4 Homozygotes

Thank you NF52 for responding so quickly. It really is remarkable that the Cornell study has had early success in 40 percent of people so far. And you are likely correct in pointing to undiagnosed diabetes and heart disease as setting the stage for AD in my relatives as well. Lately I am considerin...
by ApropoE4
Thu Apr 29, 2021 6:26 am
Forum: Announcements and Events
Topic: Gene Therapy Trial for ApoE4 Homozygotes
Replies: 49
Views: 37662

Re: Gene Therapy Trial for ApoE4 Homozygotes

Results from a second generation investigational gene therapy program show effective delivery of APOE2, the gene associated with protection against the development of Alzheimer’s disease, while also targeting and silencing APOE4, the gene that increases risk of developing the disease. A 40% reductio...
by ApropoE4
Sat Mar 06, 2021 3:35 pm
Forum: Science and Research
Topic: E4 Reactions to COVID Vaccine
Replies: 21
Views: 5205

Re: E4 Reactions to COVID Vaccine

My wife is a 3/3 and had covid arm a week after the first shot. I'm 4/4 and I had it after the second shot :)
by ApropoE4
Wed Mar 03, 2021 5:00 am
Forum: Science and Research
Topic: Covid vaccine safety for 4/4’s?
Replies: 50
Views: 14493

Re: Covid vaccine safety for 4/4’s?

I had my first Moderna vaccine a couple weeks ago which was 3 months after having Covid. About 24 hours later I came down with symptoms much like when I had Covid (mild fever, fatigue, body & head aches) that lasted about 12 hours. I felt pretty lousy. My second vaccine is in a couple weeks and...
by ApropoE4
Sun Feb 16, 2020 3:02 pm
Forum: Science and Research
Topic: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes
Replies: 29
Views: 11803

Re: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes

I thought this was presented in the original paper by Mahley and Huang. https://doi.org/10.1021/jm3008618 However, to date, the most potent phthalazinone apoE4SCs caused significant toxicity in mice. Therefore, we have expanded our validation studies to other apoE4SCs. A series of pyrazoline analogu...
by ApropoE4
Sun Feb 16, 2020 12:23 pm
Forum: Science and Research
Topic: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes
Replies: 29
Views: 11803

Re: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes

I wouldn't give mice PH002 unless I want to kill them. (actually most of my interactions with mice involved killing them so that might not be a bad thing) The molecules in e-scape bio's queue and several others are supposedly functional analogs but without the toxic effects that I assume PH002 would...
by ApropoE4
Sat Feb 08, 2020 11:09 am
Forum: Science and Research
Topic: Phase 1 Gene Therapy Trial
Replies: 2
Views: 1208

Re: Phase 1 Gene Therapy Trial

Ah, I see. It's in the announcements forum.

viewtopic.php?f=15&t=6620
by ApropoE4
Fri Feb 07, 2020 5:13 pm
Forum: Science and Research
Topic: Phase 1 Gene Therapy Trial
Replies: 2
Views: 1208

Phase 1 Gene Therapy Trial

I'm not sure if it's been mentioned here, but the trial of injecting e4/4s with a virus that changes their brains to produce a mixture of e2 and e4 (the hope is for more than half e2) has started. This seems like a promising approach, although there's no guarantee it'll be effective and won't cause ...