Because plasmalogen is a phospholipid, you'll note (Slide #73) the correlation with a specific lipid pattern: High HDL, low TGs, and especially a high HDL/LDL ratio = high plasmalogen levels. So, while we don't have definitive diet/lifesytle interventions that translate to high plasmologen, we can ...

I have one Apoe4. They wouldn’t tell me what the other one was. There's a quick way to figure it out for yourself. Open your 23andMe raw data file in a text editor like Notepad or Textedit, and search for "45412079". Likely there will only be one or two matches in the file, and one of the...

I would be curious if there's any concern over the Neu5Gc content of fish roe (a complaint I've read about beef / red meat.) While ground beef and bison supply ~25-29ug/g of Neu5Gc, fish roe is in the 400-500ug/g range. From this perspective, a prophylactic 0.5oz serving of roe (which barely provid...

I also went through every SNP that was on my promethese report and only a few of them on the PHS scale were of concern. Basically we don't know ANYTHING! If it makes me live a better life then it is worth it right? I have one sister diagnosed at 63 and another fine at 69. My 92yo mother has all her ...

I really wonder how they can have a 100 percentile unless they have the deterministic PSEN and APP genes in there? I think the PHS is a relative metric, not an indicator of absolute risk. "100" means maximum risk relative to other humans, not 100% risk. Good point, Marc. Here's a quote fr...

My PSEN and APP are all green on 23 and me so not sure how that impacted my score. I guess 50% at age 80 is better than age 60??? I failed to mention I also have a 69yo sister who is mentally intact. She hasn't had any genetic testing. Who knows right? The bottom line is we have no clue I guess.

Supposedly my polygenic hazard score percentile is 100. So basically everyone else on earth has a lower risk than me? That is super comforting. :( AZ50: 80 Not sure about when it says it will "report this value at your specific age once you turn 60 due to the nature of the Alzheimer's disease a...

Only for the brave! For a mere $99, Dash Genomics just announced that they will be making this risk score available. This polygenic algorithm (which looks at individual risk as a function of age) in computed in direct partnership with the original paper authors for anyone with 23andMe or Ancestry d...

Hi I recently started getting some of the bloodwork on the Bredesen List and my Progenalone level was 151 ng/dL with a reference range of 15 - 132 ng/dL. This is Progenelone MS. I had all my other hormone tests and was quite low as I'm perimenopausal I guess. Thinking about BHRT. I'm only 53 and sti...

Hi. My A/G ratio is 3.1 -- which is "in range" according to Dr. Bredesen. My Albumin is 5.0. My Globulin, however is slightly lower than the reference range - 1.6 (range is 1.8 - 3.8 g/dL). Should I be worried? The ration is still much over the low end for the protocol.