Search found 1139 matches
- Thu Feb 01, 2024 5:54 am
- Forum: Science and Research
- Topic: Approval of Aduhelm (aducanumab), what went wrong
- Replies: 5
- Views: 9394
Re: Approval of Aduhelm (aducanumab), what went wrong
A short recap on the controversial history of Aducanemab/Aduhelm. Aducanemab/Aduhelm was the first of the two -mab (monoclonal antibody) drugs approved by the FDA (Lecanemab/Leqembi was the 2nd, the final determination on Donanemab is currently under consideration. Gantenerumab, Solanezumab and Cren...
- Wed Jan 31, 2024 7:14 pm
- Forum: Science and Research
- Topic: Approval of Aduhelm (aducanumab), what went wrong
- Replies: 5
- Views: 9394
Re: Approval of Aduhelm (aducanumab), what went wrong
Just announced (1/31/2024) in this article: Biogen to cease production of controversial Alzheimer’s drug Drugmaker Biogen will discontinue development and marketing for Aduhelm, a landmark Alzheimer’s disease treatment that also provoked controversy over conflicting data around its efficacy, the com...
- Wed Jan 31, 2024 7:13 pm
- Forum: Prevention and Treatment
- Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
- Replies: 1808
- Views: 377124
Re: Celebration Thread! Biogen is going to the FDA with Aducan.
Just announced (1/31/2024) in this article: Biogen to cease production of controversial Alzheimer’s drug Drugmaker Biogen will discontinue development and marketing for Aduhelm, a landmark Alzheimer’s disease treatment that also provoked controversy over conflicting data around its efficacy, the com...
- Wed Jan 24, 2024 3:59 pm
- Forum: Prevention and Treatment
- Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
- Replies: 1808
- Views: 377124
Re: Celebration Thread! Biogen is going to the FDA with Aducan.
I respectfully have a different view: that J11--and I for that matter--are not celebrating drugs; we are celebrating progress in identifying SOME--but not all--drivers of Alzheimer's pathology, specifically amyloid and tau, which seem more prevalent and more toxic in ApoE 4 carriers an earlier age,...
- Wed Jan 24, 2024 6:20 am
- Forum: Prevention and Treatment
- Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
- Replies: 1808
- Views: 377124
Re: Celebration Thread! Biogen is going to the FDA with Aducan.
Your response precisely highlights my concern with you and your posts. Not once did you mention ApoE4. Despite belonging to this site for 10 years, you have refused to follow the decorum of these threads by such things as “not being bothered” to learn how to quote others. These forums are dedicated ...
- Tue Jan 23, 2024 8:24 am
- Forum: Prevention and Treatment
- Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
- Replies: 1808
- Views: 377124
Re: Celebration Thread! Biogen is going to the FDA with Aducan.
If you're not here for another celebration, you're in the wrong place! No, you’re in the wrong place. Your celebratory threads misrepresent reality and completely disregard the purpose of these forums as being dedicated to understanding the APOE-ε4 allele and how it affects health. You have co-opte...
- Mon Jan 22, 2024 8:05 am
- Forum: Science and Research
- Topic: Approval of Aduhelm (aducanumab), what went wrong
- Replies: 5
- Views: 9394
Re: Approval of Aduhelm (aducanumab), what went wrong
ApoE4s are at greater risk for brain arterial disorders (for more info refer to the ApoE4.info wiki article ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s ) I’ve written here in these forums before that this susceptibility poses a greater risk for us ApoE4s with these -...
- Mon Jan 22, 2024 8:02 am
- Forum: Prevention and Treatment
- Topic: Donanemab and Lecanemab
- Replies: 53
- Views: 233097
Re: Donanemab and Lecanemab
ApoE4s are at greater risk for brain arterial disorders (for more info refer to the ApoE4.info wiki article ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s ) I’ve written here before repeatedly that this susceptibility poses a greater risk for us ApoE4s with these -mab d...
- Wed Jan 17, 2024 10:14 am
- Forum: Prevention and Treatment
- Topic: Why Krill Oil Beats Fish Oil
- Replies: 23
- Views: 13830
Re: Why Krill Oil Beats Fish Oil
yes I read this article. Which article? Dr Patrick's Omega-3 fatty acids from her Found My Fitness website? Or her 2018 paper, the above referenced Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer’s disease "Most of the current supplements of DHA, including fish oil and...
- Tue Jan 16, 2024 1:31 pm
- Forum: Prevention and Treatment
- Topic: Why Krill Oil Beats Fish Oil
- Replies: 23
- Views: 13830
Re: Why Krill Oil Beats Fish Oil
Hi. Be careful what "Experts" you are listening to. Rhonda Patric posted a paper "Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer’s disease" To support her claims, she cited a few studies, which is odd to me that she doesn't understand them. DHA from kri...