Here's the abstract. Alzheimer’s disease (AD) is heterogenous at the molecular level. Understanding this heterogeneity is critical for AD drug development. Here we define AD molecular subtypes using mass spectrometry proteomics in cerebrospinal fluid, based on 1,058 proteins, with different levels i...

Wishing you the strength, will and energy to move forward given your news. Hope Precode can give you a good path forward in the New Year.

But she stopped playing and singing about 5 years ago. One way to get her to play might be bringing another guitarist/singer in to play with her. Does she have friends she used to play with? Is there a local instructor who might be willing to play with her? Sometimes those who have memory issues fo...

How is your thyroid? Any symptoms of infections, gut issues? Thyroid is fine. Gut is okay. I looked at Kresser's list after I got the results. I thought maybe low-level infection was a possibility because I had been exposed to someone with Covid about a month before, but never got sick or tested po...

However I am wondering if there is any dangers of bacteria or disrupting the nasal cavity biosphere that might increase the risk of alzheimers? I've been using one irregularly since 2019. Dr. Craig Tanio, who is on Bredesen's physician round table, recommended it to me when I was living in Florida....

So, got my recent labs back and there was a major jump in LDP-P. Almost double, from 1266 in January to 2442 in November. :shock: Never, ever had anything over 1420 in the last 10 years, even when doing higher saturated fat (coconut products). LDL-small (417) and -medium (530), and ApoB (101) were a...

Have any other APOE's had a similar experience with dizziness or any theories I could research? I was diagnosed with Meniere's many years ago after a similar round at the doctors. And I could never really link my vertigo to anything. It just came and went, but when it came, it would be wicked and s...

Early in the clinical research cycle, but in this phase, 62% of the participants were ε4 carriers. Allopregnanolone, a first-in-class regenerative therapeutic, has the potential to delay neurodegeneration in early Alzheimer's disease (AD) by promoting endogenous systems of renewal and repair, early ...

My father took the Quest test, and it said his result was "intermediate." He then went through the initial testing for the AHEAD trial, and they said his blood amyloid levels were low, and he didn't qualify for the trial — solidifying my belief that the Quest test is giving people scary r...

I'm sure some of you have had to deal with these issues, so I'm curious how you thought about it! I think you need to respect your mom's desire not to know, and therefore you don't share your status to your half-siblings. Once that info is out there, it could to easily get back to her. However, has...