I skimmed through the Microbiome Digest for the first time in a while. Here are a few open access papers that might be of interest. Altered microbiomes distinguish Alzheimer’s disease from amnestic mild cognitive impairment and health in a Chinese cohort (but note there may be an educational attainm...

The WHO issued a guidelines document for reducing the risk of dementia. As you would expect from a document which made it through the politics of a massive organization, there didn't seem to be anything for readers of this forum to learn from the guidelines. (And, in fact, some things which you'll p...

I'd follow the authors' inclination to wait for a better study regarding the statin/non-statin effects before making any changes to a statin regimen. (As usual with AD, lots of intriguing notions, far fewer well proven conclusions.)

The associations of sdLDL-C or Lp(a) on cognitive change were more pronounced in statin users. What was the association with out the statin? My cholesterol sucks, but If I don't take a statin, does the risk diminish significantly, or only a little...? The association of sdLDL-C and cognitive declin...

An apropos insight for this group into relative risk: To contextualize, the observed strength of association of the highest quintile of ApoB with 15-year change in global z score (i.e., −0.10) was almost comparable to 15-year change in global z score seen with the presence of 1 APOE e4 allele (i.e.,...

ApoB, small-dense LDL-C, Lp(a), LpPLA2 activity, and cognitive change [ Paywalled ] Yashashwi Pokharel, Farah Mouhanna, Vijay Nambi, Salim S. Virani, Ron Hoogeveen, Alvaro Alonso, Gerardo Heiss, Josef Coresh, Thomas Mosley, Rebecca F. Gottesman, Christie M. Ballantyne, Melinda C. Power Neurology Ma...

Thanks Brian! I've never felt any brain effects from curcumin, but it does help my brain. I guess I'll go for the 180 mg/day, but I wonder if they're doing any larger followup studies. Here's an open access link for the 2018 paper: Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of ...

A few more details at Science Daily: https://www.sciencedaily.com/releases/2019/04/190430121800.htm "We proposed a new name to increase recognition and research for this common cause of dementia, the symptoms of which mimic Alzheimer's dementia but is not caused by plaques and tangles (the buil...

Absent any science to guide me, maybe based on my thin phenotype I can reduce my twice a day Theracurmin to once a day and save a little $. my guess is that it will be somewhat individual. You will need to find your own sweet spot. Try a smaller dose and see if you notice a difference... If I remem...

https://www.beingpatient.com/fasting-mimicking-diet/ "Gallstone formation goes way up for people who fast regularly for 16 or more hours, and they may need their gallbladder removed. If people skip breakfast, they also face an increased risk of cardiovascular mortality, so I would not fast for...