Thanks NF52

My mom passed quietly yesterday. She was 76. It was an odd situation, with her care facility in lock down. No one had seen her in weeks, except by phone. It was just the end stage of the disease, nothing unexpected at this point. But she got good care and was able to be transferred out in time that ...

Hi Eric. Yes, I was on atorvastatin 20 or 40mg for 3-4 years. Before that my cardiologist had me on the high dose, slow release niacin - which has fallen out of favor now. I started to have the muscle issues that are sometimes associated with statins. 40 mg really was tough. After I got a clean calc...

Hi NF52. Thank you! I've been away from the site for a few days as I shut down my lab and started to transition to teaching online. My mom's memory care facility was locked down a few days ago - she is fine but of course I worry abut how all this will play out in the coming weeks. You are absolutely...

What I know, there are *correlated* with greater HDL: niacin, statins, higher estrogen/lower testosterone patterns in females vs. males (up until menopause). This is from memory, I haven't red about this in a year or so.

Hello everyone, I don't know if this has been posted before. I didn't see it when I checked. This table: https://www.nature.com/articles/s41467-019-14279-8/tables/2 From this recent study: https://www.nature.com/articles/s41467-019-14279-8 Really brought me down. I guess it's been a while since I re...

Hi. Thanks for sharing. The disconnect between the scale of the problem and the resistance to doing much of anything to reduce risk at the level of populations is disappointing. In our area we have horrible air pollution, mostly PM2, one of the older populations of any state, and high and increasing...

I read this. Thanks for sharing! It's a good overview of the current apoe4 research. It might be worth linking somewhere for new folks. I wish they were further along on these approaches to addressing apoe4 directly.

I love plant polyphenols and I'm not surprised that they reduce risk. They found reduced risk associated with kaempferol, myricetin, and isorhamnetin. They state they found not risk reduction associated with quercetin but their data kind of suggests that a larger study might detect that as well. I'm...

Years back I had high hopes for their apoe4 "structure correcters" That research hasn't seemed to move along as quickly as hoped. But I'm glad they're still at it!