AD/PD™ 2022​ brings a new look and a new chapter in the history of the AD/PD™ series of conferences. By merging together with the AAT-AD/PD™ Advances in Alzheimer’s Therapies Focus Meeting, AD/PD™ is now transformed into an annual meeting, with a continuing focus on the ADVANCES IN SCIENCE & TH...

You may find Peter Attia's two newsletters on "Does low cholesterol cause cognitive impairment?" useful, particularly part 2 in which he discusses plasma desmosterol level as a potential indicator for statin use increasing the possibility of AD. Does low cholesterol cause cognitive impairm...

Preprint. Mouse model. Confirms Brian's biases. https://www.biorxiv.org/content/10.1101/2022.03.01.480612v1 APOEϵ4 and exercise interact to influence systemic and cerebral risk factors for dementia Kate E. Foley, Cory A. Diemler, Amanda A. Hewes, Dylan T. Garceau, Michael Sasner, Gareth R. Howell do...

Wow! You made my day! The evidence continues to build that there's no more point in paying attention to science, so maybe I'll find a tetherball somewhere :lol: :lol: Of course, skepticism is an important part of the scientific process. And we'd all really like it if dementia had, exclusively, simp...

Open access. Interesting for those who want to assess risk based on SNPs and, perhaps, those who want to worry less based on past genetic testing maybe not reflecting actual risks. https://alzres.biomedcentral.com/articles/10.1186/s13195-022-00962-4 Challenges at the APOE locus: a robust quality con...

Interesting. Mouse model. Probably too early to draw broad conclusions for your lifestyle, but does provide one more potential mechanism for suggesting how sleep disturbance leads to dementia. Science Daily explainer: https://www.sciencedaily.com/releases/2022/02/220210154215.htm Open access paper: ...

A story from a caretaker about his life, health challenges, and relationship with his wife, who has been taken by early onset dementia. Sad and heartwarming.

https://thewalrus.ca/when-my-wife-devel ... connected/

Negatives: Paywalled paper & fruit fly APOE4 model. But an interesting lead if it bears out. Science Daily explainer: https://www.sciencedaily.com/releases/2022/01/220103121721.htm The brain has a natural protective mechanism against Alzheimer's disease, and researchers ... have discovered that ...

Brian is a great, smart guy--but I think he's a good bit younger than this grandmother of two! NF52, your assessment is very generous :) As for the age thing, well my younger brother is a grandfather of three. But at least I still have a few months before I need to sign up for Medicare ... (And I a...

Assuming they can establish a meaningful RCT, it will be interesting to see clinical results in humans. Article: https://gladstone.org/news/can-already-approved-drug-treat-alzheimers-disease Researchers at Gladstone Institutes teamed up with scientists from UC San Francisco (UCSF) and Icahn School o...