I realize that the comment inbox is quite fill at this time, though thinking through the above CTAD result seems to be of considerable importance. How should we interpret the above result? Firstly, it should be noted that we are not back in the times when there were only low n's available. Almost an...

The above slide from the Donanemab presentation at CTAD was the mic drop moment for me. It will take some time to talk through this slide, though it appears to present a very new view on mab efficacy that greatly changes what has been reported to this thread for the last 4 years. What are we seeing ...

Why has this thread went from Celebration to Jubilation over the last few months? Why has a feeling of euphoria emerged? That is a reasonable question for those who might not have seen the posts from CTAD 2023 that provoked this response. If we want to talk about this change in thread tone, then tha...

I want to work through the comment inbox, though the celebration inbox is just getting super jammed up. It might take some time to catch up with it all. The new celebration that has only now reached my attention was from the TB-2 JAMA article. That article was from July of 2023. It was only in the l...

Thank you for your comment ChicagoGirl! I will need to postpone the celebration as I work my way through my jammed inbox. Yes, lithium has been quite interesting. From my experience, lithium has been a mood enhancer and a cognitive enhancer. It is one of those funny things where you try something li...

I am not sure whether people are going to be happy about this, but there is another celebration incoming.
Just to moderate expectations I will put this one more in the category of an observation than a "discovery", nonetheless this is a big one.

Oh yeah! Oh yeah!

J11! J11! J11!

TheresaB, thank you very much for your comment! I greatly appreciate diverse opinions, though I had entirely unexpected the nature of your opinion. There has been an ongoing stream of extremely positive news that has been reported over the last few months and I had not imagined how one might interpr...

Oh Yeah! Oh Yeah! Huge Huge news! If you're not here for another celebration, you're in the wrong place! Announced today that a tau 217 blood test by AlzPath is ready to detect AD. Large study found that it can detect AD 15 years forward. That is exactly what we were looking for. $300? Just massive....