Search found 629 matches

by Fiver
Tue Aug 25, 2020 12:47 pm
Forum: Our Stories
Topic: Need some guidance
Replies: 5
Views: 2241

Re: Need some guidance

Hi LC-FL, A few things come to mind, which might be helpful. PS - I'm not a doctor. Tincup is right about blood sugar control being something to look at, and it's something you can address now. If he recently retired maybe he is not as active and constantly training for work. Maye he can find someth...
by Fiver
Wed Aug 19, 2020 10:12 am
Forum: Science and Research
Topic: 4 drugs which may get approval in 3-5 years
Replies: 3
Views: 2647

Re: 4 drugs which may get approval in 3-5 years

very interesting and helpful! Thanks. I little bit of good news for my day. :)
by Fiver
Wed May 27, 2020 9:09 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 8571

Re: Alzheimer's Afternoons Seminar Series Summaries

Good question. I noticed some differences too. I don't know the specific answer for their studies but overall the researchers are using different models - usually mice, but often different strains - in different ways. The iPSC cells can be different, even different cell types. Sometimes the cells ar...
by Fiver
Wed May 27, 2020 9:03 am
Forum: Science and Research
Topic: APOE4 protective against melanoma
Replies: 1
Views: 1184

Re: APOE4 protective against melanoma

Hi BrianR, I also saw this one: https://www.nature.com/articles/s41591-020-0879-3 Mice expressing the human APOE4 allele exhibited reduced melanoma progression and metastasis relative to APOE2 mice. APOE4 mice exhibited enhanced anti-tumor immune activation relative to APOE2 mice, and T cell depleti...
by Fiver
Fri May 15, 2020 7:54 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 8571

Re: Alzheimer's Afternoons Seminar Series Summaries

Dr. Elizabeth Head, Professor, University of California Irvine Alzheimer’s disease in Down syndrome: Link between Cerebrovascular pathology On Thursday, May 14, 2020 Dr. Liz Head presented her work on Alzheimer’s disease in Down Syndrome. Why would it be useful to study the pathology of AD that is a...
by Fiver
Thu May 14, 2020 3:40 pm
Forum: Prevention and Treatment
Topic: PREPRINT: Increased risk from COVI-19 in apoe4s
Replies: 10
Views: 4269

Re: PREPRINT: Increased risk from COVI-19 in apoe4s

Yep. I agree. I expected it too. Still, it seems like piling on.
by Fiver
Thu May 14, 2020 12:55 pm
Forum: Prevention and Treatment
Topic: PREPRINT: Increased risk from COVI-19 in apoe4s
Replies: 10
Views: 4269

PREPRINT: Increased risk from COVI-19 in apoe4s

https://www.medrxiv.org/content/10.1101/2020.05.07.20094409v1 Full text: https://www.medrxiv.org/content/10.1101/2020.05.07.20094409v1.full.pdf+html APOE E4 GENOTYPE PREDICTS SEVERE COVID-19 IN THE UK BIOBANK COMMUNITY COHORT View ORCID ProfileChia-Ling Kuo, View ORCID ProfileLuke C Pilling, View OR...
by Fiver
Tue May 05, 2020 9:58 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 8571

Re: Alzheimer's Afternoons Seminar Series Summaries

Yep. There seems to to be several things going on with blood vessels - hardening, unresponsiveness, cerebral coronary amyloidosis, leakiness of the blood brain barrier. And apoe4 seems to contribute to most if not all of them. :(
by Fiver
Mon May 04, 2020 8:42 am
Forum: Science and Research
Topic: Apoe4 leads to BBB disfunction
Replies: 3
Views: 1895

Re: Apoe4 leads to BBB disfunction

Hi Stefan. I have to read this one soon. I'll see what I can access and share.
by Fiver
Mon May 04, 2020 8:40 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 8571

Re: Alzheimer's Afternoons Seminar Series Summaries

Sex differences in metabolic and vascular contributions to dementia. April 30, 2020 Dr. Kristen Zuloaga is an Associate Professor of Neuroscience and Experimental Therapeutics (DNET) at Albany Medical College. A list of her group’s recent publications can be found here: http://www.zuloagalab.com/pu...