So, got my recent labs back and there was a major jump in LDP-P. Almost double, from 1266 in January to 2442 in November. :shock: Never, ever had anything over 1420 in the last 10 years, even when doing higher saturated fat (coconut products). LDL-small (417) and -medium (530), and ApoB (101) were a...

Have any other APOE's had a similar experience with dizziness or any theories I could research? I was diagnosed with Meniere's many years ago after a similar round at the doctors. And I could never really link my vertigo to anything. It just came and went, but when it came, it would be wicked and s...

Early in the clinical research cycle, but in this phase, 62% of the participants were ε4 carriers. Allopregnanolone, a first-in-class regenerative therapeutic, has the potential to delay neurodegeneration in early Alzheimer's disease (AD) by promoting endogenous systems of renewal and repair, early ...

My father took the Quest test, and it said his result was "intermediate." He then went through the initial testing for the AHEAD trial, and they said his blood amyloid levels were low, and he didn't qualify for the trial — solidifying my belief that the Quest test is giving people scary r...

I'm sure some of you have had to deal with these issues, so I'm curious how you thought about it! I think you need to respect your mom's desire not to know, and therefore you don't share your status to your half-siblings. Once that info is out there, it could to easily get back to her. However, has...

Interesting that they used the association of BCAAs between T2D and AD and found that lowering BCAAs made a difference in AD progression in their mouse model. Shin learned about the benefits of the compound, BT2, through his research into the brain and neurodegenerative disorders during the past 10 ...

Increasing calories (and anaerobic exercise) makes sense, through doing so with carbs (admittedly consistent with these recommendations) would require a shift in perspective (vs. just eating more of my current diet) and potentially raise concern about oxidized LDL (advanced glycation end products; ...

Physical Challenges: Feel very fit but underweight Cardio excellent but muscle mass lacking aerobic - 90% anaerobic - 10% Appetite Challenges: Hungry most afternoons, even after meals. Caloric deficit? Nutritionally deficient? I do a similar diet, the final piece going low oxalate almost 3 years ag...

I'm going to switch to a 12 hour eating window to fit in more meals and fatten up. I won't be able to exercise very much on my trip so hopefully that will also provide an opportunity to gain weight. I'm traveling with 3 pounds of nuts, cans of mackeral, and packets of olive oil. From a fellow, stru...

This seems like a sensible approach to me (?) Homocysteine is an easy test, so probably worth doing before you throw TMG (betaine) in the mix. Some people can control high homocysteine just with folate, B12, and B6 supplementation. If you want to do a deeper dive into all things related to folate, ...