I read a story today about a study that came out in January about druggable sites in ApoE4 and it found something they referred to as CBA2 as a candidate for a drug to improve lysosomal autophagy. Story: https://medicalxpress.com/news/2024-02-team-potential-alzheimer-drug.html Research: https://www...

Last month CBS's 60 minutes broadcast an episode on “celebratory” news of a neurosurgeon addressing Alzheimer’s through focused ultrasound to open the blood-brain barrier in order to apply the anti-amyloid antibody aducanumab. The treatment did indeed reduce amyloid — BUT DID NOT REPORT ANY COGNITIV...

I'm in an APOE 4/4 in a large family with no family history of dementia*. I have five siblings in their 50s/60s and 2 kids in their 20's. None of them have had DNA tests as far as I can tell, but my kids must have at least one E4 and odds are most of my siblings are one E4 or worse. Here's my story...

Welcome Tony, your English is impressive! For carbohydrate, which types of carbohydrate will you recommend? I saw sugar and cereal were all banned from list. You're right, not all carbs are created equal. Maybe a visual will help, the KetoFlex pyramid ketoflex brain pyramid.jpg You see that non-star...

You are already doing many important things that will help delay/avoid dementia. Good for you! I am here because I still have a slim hope that prevention or delay might be possible, so I would like to learn what I can. I also am interested in others stories. I am here to tell you there is hope! I wi...

Thanks Theresa for sharing. Unfortunately I can’t open the page. Can you please check the link? I linked to the wiki's main page, if you scroll down, the article is there, but I'll make it easier, here's the link to the exact ApoE4.info wiki page: Beneficial (and some negative) Plant/Natural Chemic...

The study demonstrates that phyllodulcin inhibits the aggregation of amyloid β (Aβ), a main cause of AD, and decomposes existing Aβ clumps. In an animal model, phyllodulcin reduced memory impairments, decreased deposition of Aβ in the hippocampus, and minimized neuroinflammation, key factors in AD....

From this article The 6 best 23andme alternatives in 2024 *Try AncestryDNA if you want one of the best overall genetic testing experiences. *Try MyHeritage if you want to connect with long-lost relatives. *Try Living DNA if you want to deep dive into your familial history and ancestors. *Try FamilyT...

If you haven’t read the APOE4.info wiki Introduction to APOE4 lately, now might be a good time to revisit. It has had quite a number of updates the past few weeks. There have been some really interesting papers published recently. Adding them led to other updates, sprucing up, and additional graphics.

I don't personally have a recommendation, but maybe this article might offer a good option for you.

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