Search found 763 matches

by MarcR
Fri Feb 05, 2021 12:14 pm
Forum: Prevention and Treatment
Topic: APOE 4/4 Combat sports
Replies: 9
Views: 3145

Re: APOE 4/4 Combat sports

If anyone could possibly help point in the right direction that would be hugely appreciated Cheers The discussion and strategizing here around macronutrient ratios is all about curing and avoiding metabolic dysfunction. Just about any ratio can work. Your normal sugars and superior body composition...
by MarcR
Thu Feb 04, 2021 10:52 pm
Forum: Science and Research
Topic: Higher phosphatidylcholine protects against dementia
Replies: 69
Views: 26537

Re: Higher phosphatidylcholine protects against dementia

Thanks for the explanation, MoJoe. I can see that this issue is complex and that there are open questions that will require time to answer. I think you make a good point about the large dosage differences and the uncertain comparative dose relationships among plasmalogen supplements with varying ent...
by MarcR
Thu Feb 04, 2021 6:53 pm
Forum: Science and Research
Topic: Higher phosphatidylcholine protects against dementia
Replies: 69
Views: 26537

Re: Higher phosphatidylcholine protects against dementia

Definitely worthy of a read if you are seeking plasmalogens and extra choline from food. According to Dr. Dayan Goodenowe, plasmalogen does not survive digestion. Our own cells must synthesize it in the peroxisome and the endoplasmic reticulum organelles. As we age, peroxisomal function deteriorate...
by MarcR
Tue Dec 01, 2020 9:28 am
Forum: Prevention and Treatment
Topic: Low insulin pathway to dementia?
Replies: 17
Views: 6291

Re: Low insulin pathway to dementia?

Dale Bredesen's Type 3 Alzheimer's classification? When I ask him about factors mentioned by Bredesen in Type 3 diabetes Joe, I want to be sure that I communicated this point about Type 3 Alzheimer's effectively. Bredesen's schema includes four types of Alzheimer's: Type 1 : Inflammatory. Chronic i...
by MarcR
Mon Nov 30, 2020 10:20 am
Forum: Prevention and Treatment
Topic: Low insulin pathway to dementia?
Replies: 17
Views: 6291

Re: Low insulin pathway to dementia?

Joe, I agree with Tincup that you don't seem insulin resistant. Do you continue to meet the criteria for a positive dementia diagnosis today? If so, I wonder if you have something else going on. Are you familiar with Dale Bredesen's Type 3 Alzheimer's classification?
by MarcR
Thu Nov 12, 2020 2:58 pm
Forum: ApoE4.Info, Inc.
Topic: Upcoming site access issue (Let's Encrypt)
Replies: 3
Views: 16335

Upcoming site access issue (Let's Encrypt)

The problem. If you use a device running an Android version prior to 7.1.1, beginning January 11 your access from that device to this site and many others will be impaired. (7.1.1 was released only four years ago, and a third of all Android devices are running older versions.) When you attempt to v...
by MarcR
Tue Oct 27, 2020 6:37 pm
Forum: Science and Research
Topic: APOΕ4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis
Replies: 26
Views: 8929

Re: APOΕ4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis

I agree that Fiver's summary is excellent and would also like to thank everyone participating in this fantastic topic.
by MarcR
Sun Sep 20, 2020 1:46 pm
Forum: Prevention and Treatment
Topic: Breakthrough on Deep Sleep Issue
Replies: 7
Views: 3489

Re: Breakthrough on Deep Sleep Issue

I learned that restless legs can impact deep sleep from my Oura 2 Ring as it measures "restlessness" and that measure has dropped along with improvements in deep sleep. It sounds as though the Oura 2 estimates deep sleep by tracking "restlessness" as a surrogate marker. One of t...
by MarcR
Sun Aug 16, 2020 9:59 pm
Forum: Prevention and Treatment
Topic: Discount for 100% pastured beef
Replies: 6
Views: 2595

Re: Discount for 100% pastured beef

I have been a satisfied monthly subscriber to the Prairie Ground Box since last November. Recommended!
by MarcR
Sun Jun 28, 2020 8:27 pm
Forum: Our Stories
Topic: 3/4 new here with high LDL after 3-months keto
Replies: 22
Views: 8221

Re: 3/4 new here with high LDL after 3-months keto

Great handle and first post, apoe4thebetter - welcome. You seem to have a solid strategy and are refining and optimizing rather than fixing big problems - congratulations on being so well-positioned for an extended health span. I imagine that you are familiar with Dave Feldman's work, but just in ca...