It's all known for years, and was discussed here. Amyloid is an antimicrobial and part of the innate immune system. Researchers did not exclude this function so far from the pathologic process, but still only a few want to think further and test the brain infection hypothesis. It is a global self-sc...

In case you are wondering: B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax Also Known As: APP/PS1 APP/PS1 are double transgenic mice expressing a chimeric mouse/human amyloid precursor protein (Mo/HuAPP695swe) and a mutant human presenilin 1 (PS1-dE9), both directed to CNS neurons. Both mutations are associated...

Following is a layman's opinion. I think the issue is broader than just lectins, but also more simple. Simple because any frequent high pressure in the gut with time probably increases inflammation. Broader because then any combination of gas-producing food plus immobile life style would increase th...

Slowly the science establishment also gets the idea of a brain microbiome, through this conference paper: 594.08 / YY23 - The human brain microbiome; there are bacteria in our brains! https://abstractsonline.com/pp8/#!/4649/presentation/32057 Science: Do gut bacteria make a second home in our brains...

Am I correct in understanding that Amyloid-beta (Aß) is the peptide produced by our immune system and beta-amyloid is the plaque found in the brain which is associated with AD? The words define the same entity. However there are beta-amyloids of different length so the one produced for immune purpo...

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice. Ilievski V, Zuchowska PK, Green SJ, Toth PT, Ragozzino ME, Le K, et al. (2018) PLoS ONE 13(10): e0204941. https://doi.org/10.1371/journal.pone.0204941 &q...

Very good (or bad). I think a next step in the research would be to determine which agent is responsible that passes through the IB: is it extracellular vesicles (from gut bacteria), or is it (living or dead) bacterial cells, that cause sufficient, and permanent inflammation of neural tissue. Which ...

Could the NYT not have been more detailed? I mean it's not exactly rocket science what 23aNdme is doing. Mutation screening (at many positions at the same time) is done using microarrays, and if there is an error rate the manufacturer of the microarrays is to blame. Poor investigation, maybe intenti...

See previous thread.

NewRon wrote:Why are they afraid to publish their studies?

https://en.wikipedia.org/wiki/Academic_bias

It's well known in the Alzheimer's research area. The "wrong" publication might damage their career.