Search found 3351 matches

by J11
Thu Jan 18, 2024 7:00 pm
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 346706

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

There are a few back items that have been piling up in the outbox and this is one of them. The bottom figure has been posted a few times to thread, but I'll post it again because it is a good. What we can see are 4 dementia scales boxed in red in the center of the bottom figure. We have CDR-sb, ADCO...
by J11
Thu Jan 18, 2024 6:46 pm
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 346706

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

This is where the 2 step AD plan enters the picture. Step 1: Clear Amyloid. Check. For some patients who are early enough this could stop progression, though there is still quite a bit of uncertainty of exactly when is early enough. Step 2: Clear tau. Treating with tau could then be a highly powerfu...
by J11
Thu Jan 18, 2024 6:40 pm
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 346706

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

I went through clinical trials gov to find the AD trials with anti-amyloids. The total enrollment exceeded 37,000. Admittedly several of these are large registry trials (like the one form CMS with a target enrollment of 8,680) which are only getting started, though there are now many many others tha...
by J11
Thu Jan 18, 2024 6:11 pm
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 346706

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

This is a super super exciting time in clinical Alzheimer's! We are moving away from mere celebration to jubilation! This is only monotherapy anti-amyloid mab? and we are running out of end zone?? The TB-2 disease model analysis has largely ended any relevant rebuttal against anti-amyloid mabs. 95% ...
by J11
Tue Jan 16, 2024 6:54 pm
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 346706

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

This is one of the thread favorites that has been posted several times previously and can illustrate an important point about the longer term benefits of mabs. It also helps to provide some context for the meaning of 95% slowing etc.. The figure is for the Emerge extension and considers the cognitiv...
by J11
Tue Jan 16, 2024 6:13 pm
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 346706

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

There is a lot to work through to make sense of the Disease Model Time presented at CTAD. One of the first points to start in understanding how the model might influence patient outcomes is to think about the Baseline for the mab trials. On the bottom we see the Baseline for Clarity. I boxed the ite...