Search found 127 matches

by xactly
Tue Jan 21, 2020 12:13 pm
Forum: Prevention and Treatment
Topic: When to take the supplements?
Replies: 1
Views: 1342

Re: When to take the supplements?

I have not been able to find in Bredesen's book a recipe of when to take each supplement (maybe there is, but I have not found it). Of course, melatonin is before sleeping. But what about the other pills? B12 / folate / D3 & K2 / ...? Does it matter when to take them? All at the same time? Sepa...
by xactly
Sun Jan 05, 2020 10:17 am
Forum: Science and Research
Topic: Peter Attia #85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health
Replies: 5
Views: 2880

Re: Peter Attia #85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health

I did find this article Training Center: Why heart rate shouldn't be ignored which suggests that, once you've developed a lactate utilization profile and correlated it with heart rates, you can use heart rate as a proxy to define your zone. And you might also be able to use disciplined time trial t...
by xactly
Sat Jan 04, 2020 8:09 am
Forum: Science and Research
Topic: Peter Attia #85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health
Replies: 5
Views: 2880

Re: Peter Attia #85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health

I'm going to modify my own exercise regimen around this Zone 2 conditioning framework. The explanations of how lactate works in the body (and its role in cancer) were superb. The discussion really connected a lot of metabolic pathways and concepts for me. I would also like to modify my exercise reg...
by xactly
Sat Dec 28, 2019 7:14 pm
Forum: Prevention and Treatment
Topic: Zero carb diet will help prevent Alzheimer’s
Replies: 126
Views: 58401

Re: Zero carb diet will help prevent Alzheimer’s

In our upcoming book, Dr. Bredesen adds an Omega-3 index goal of greater than 10% for E4 carriers. If you decide to experiment with using only plant sources (which feels a bit risky to me, but may work given your favorable genetics) you are in a perfect position to inform us all. Here's a link for ...
by xactly
Fri Dec 27, 2019 9:48 am
Forum: Science and Research
Topic: Peter Attia #85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health
Replies: 5
Views: 2880

Re: Peter Attia #85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health

I also am finding this episode fascinating. I'm about halfway through. I am particularly interested in the statement that lactate is an important fuel source for the body and brain. It is not, as is popularly thought, a waste product. San Millan states that lactate is actually a better fuel for the ...
by xactly
Mon Dec 23, 2019 2:52 pm
Forum: Prevention and Treatment
Topic: Zero carb diet will help prevent Alzheimer’s
Replies: 126
Views: 58401

Re: Zero carb diet will help prevent Alzheimer’s

A worry I have is that the effect: "It [natural selection] couldn't care less about genes and lifestyle choices that keep you physically and mentally healthy into old age" validly made by xactly might be worse than "couldn't care". It might be "antagonistic pleiotropy"...
by xactly
Mon Dec 23, 2019 2:43 pm
Forum: Prevention and Treatment
Topic: Zero carb diet will help prevent Alzheimer’s
Replies: 126
Views: 58401

Re: Zero carb diet will help prevent Alzheimer’s

We always talk about how there is no ONE diet that will work for all of us. We are each a compilation of so much more than our shared ApoE4 allele(s). That said, evidence is strongly converging to demonstrate that the single most important thing our population can do is to avoid insulin resistance,...
by xactly
Fri Dec 20, 2019 11:03 am
Forum: Prevention and Treatment
Topic: Zero carb diet will help prevent Alzheimer’s
Replies: 126
Views: 58401

Re: Zero carb diet will help prevent Alzheimer’s

I read this thread with interest. I am choosing a different approach to diet. My family has a strong history of heart disease. My father, a trim and fit individual, died of a myocardial infarction while hiking on the Appalachian Trail two weeks after his 50th birthday. Four of his five siblings also...
by xactly
Fri Dec 20, 2019 7:09 am
Forum: Prevention and Treatment
Topic: What's the best strategy?
Replies: 2
Views: 1383

Re: What's the best strategy?

I would be inclined to say it's worth concentrating on all the major influence points because they are beneficial for health and longevity, regardless of the diagnosis. In my mind, those points of influence are: 1) exercise; 2) high quality sleep; 3) diet (including key supplements) ; 4) stress mana...
by xactly
Thu Dec 19, 2019 9:29 am
Forum: Prevention and Treatment
Topic: Is anyone taking Metformin for longevity (or considering it)?
Replies: 19
Views: 7287

Re: Is anyone taking Metformin for longevity (or considering it)?

I took Metformin briefly earlier this year. I'm a healthy older adult without metabolic disorder or diabetes. I discontinued use after a couple of months when Peter Attia shared research showing Metformin blunts the positive effects of exercise in healthy people. Interestingly, and possibly related ...