A clip from the study comments below. I did read somewhere that salsalate has fewer gastric side effects than aspirin (which I take). So, while understanding that this was a mouse study, I'm wondering for those of us who are 4/4, (& btw, not getting any younger!!) the chance to possibly prevent ...

My thinking here based on my understanding (limited as it is at this point) of the complexities of the AD process, is that for those of us who do have methylation issues specifically due to mutations of MTHFR (w/emphasis on 2 copies which severely limit the ability to use folate) is that we can't af...

Also whether the MTHFR gene was controlled for. I'd also like to know what folate formulation was used. My thinking here being that if the study included those with the MTHFR mutation (esp 2 copies), then adding the methylated forms of folate & B12 might contribute to the improvements seen? Just...

I am new to this site and so excited to have found it! Since learning my ApoE status a couple of years ago (during a routine blood test), I have felt very much alone and have been doing my own research. I've been following Dr. Mahley and the Gladstone for some time and feel hopeful about their resea...