Hi BrianR, I also saw this one: https://www.nature.com/articles/s41591-020-0879-3 Mice expressing the human APOE4 allele exhibited reduced melanoma progression and metastasis relative to APOE2 mice. APOE4 mice exhibited enhanced anti-tumor immune activation relative to APOE2 mice, and T cell depleti...

Dr. Elizabeth Head, Professor, University of California Irvine Alzheimer’s disease in Down syndrome: Link between Cerebrovascular pathology On Thursday, May 14, 2020 Dr. Liz Head presented her work on Alzheimer’s disease in Down Syndrome. Why would it be useful to study the pathology of AD that is a...

Yep. I agree. I expected it too. Still, it seems like piling on.

https://www.medrxiv.org/content/10.1101/2020.05.07.20094409v1 Full text: https://www.medrxiv.org/content/10.1101/2020.05.07.20094409v1.full.pdf+html APOE E4 GENOTYPE PREDICTS SEVERE COVID-19 IN THE UK BIOBANK COMMUNITY COHORT View ORCID ProfileChia-Ling Kuo, View ORCID ProfileLuke C Pilling, View OR...

Yep. There seems to to be several things going on with blood vessels - hardening, unresponsiveness, cerebral coronary amyloidosis, leakiness of the blood brain barrier. And apoe4 seems to contribute to most if not all of them.

Hi Stefan. I have to read this one soon. I'll see what I can access and share.

Sex differences in metabolic and vascular contributions to dementia. April 30, 2020 Dr. Kristen Zuloaga is an Associate Professor of Neuroscience and Experimental Therapeutics (DNET) at Albany Medical College. A list of her group’s recent publications can be found here: http://www.zuloagalab.com/pu...

Alzheimer’s Afternoon Seminar Series Dr. Shannon Macauley April 28, 2020 Targeting vascular KATP channel activity in Alzheimer's disease Takeaway: Sulfonylurea drugs used to treat diabetes seem to inhibit the accumulation of Aβ by restoring vascular health and calming neuronal activity in the brain...

Alzheimer’s Afternoon Seminar Series APP and Bioenergetics Dr. Heather Wilkins, University of Kansas Medical Center April 23, 2020 Takeaway: The process of degrading old, malfunctioning mitochondria and replacing them with young, healthy mitochondria is important but slows with age (perhaps more in ...

Enhanced skeletal muscle as a novel determinant of CNS aging and Alzheimer’s disease Alzheimer’s Afternoons Seminar Series (April 21) Dr. Constanza J. Cortes, Brain Aging Physiology Lab, University of Alabama Birmingham Takeaway: A robust lysosomal waste disposal system in muscle tissue promotes he...