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by Fiver
Thu Aug 29, 2019 6:40 am
Forum: Prevention and Treatment
Topic: Epigenetics - can we really turn APOE4 off?
Replies: 30
Views: 7484

Re: Epigenetics - can we really turn APOE4 off?

Hi Mike, interesting. I hadn't been thinking that apoe4 improves ketone metabolism. I can see how it might, indirectly, especially is sugar metabolism is compromised. I'll read up on that! Thanks. I'll admit that over time I've kind of lost interest in the evolutionary story of apoe4, human diets, e...
by Fiver
Thu Aug 29, 2019 6:19 am
Forum: Science and Research
Topic: APOE4 Carriers Have Memory Problems Before the Onset of Alzheimer's
Replies: 6
Views: 1995

Re: APOE4 Carriers Have Memory Problems Before the Onset of Alzheimer's

Hi Circular. Interesting. Me too. I've always known that my brain didn't quite work like others. "Processing steps" is a good way to put it. I've felt like I use alternate "pathways" or parts of my brain to do things that came naturally to others. I feel like I use the creative, ...
by Fiver
Wed Aug 28, 2019 12:59 pm
Forum: Science and Research
Topic: APOE4 Carriers Have Memory Problems Before the Onset of Alzheimer's
Replies: 6
Views: 1995

Re: APOE4 Carriers Have Memory Problems Before the Onset of Alzheimer's

Interesting TelopeaB - thanks for sharing that.

I suppose this isn't surprising. And while it is a bit terrifying (I need my brain working at least fairly well) it also makes an excellent point - that this is not something that just becomes a problem for some people when they are "old".
by Fiver
Wed Aug 28, 2019 11:10 am
Forum: Science and Research
Topic: Lifestyle changes may not help Apoe4s
Replies: 14
Views: 3589

Re: Lifestyle changes may not help Apoe4s

This is counter to some of the other recent studies showing that lifestyle improvements helped E4s as much or more, compared to E3s/E2s. I suppose it would make sense that E4s would have a harder time "recovering" later in life, or maybe anytime in life. But I'll wait for more studies and ...
by Fiver
Tue Aug 27, 2019 5:54 pm
Forum: Prevention and Treatment
Topic: Epigenetics - can we really turn APOE4 off?
Replies: 30
Views: 7484

Re: Epigenetics - can we really turn APOE4 off?

Hi Mike. Hope you're well. I've read solid reviews and articles in good journals, which disagree on it entirely. I think you have good points. apoe4 does bind poorly to the LDLr (low density lipoprotein receptors) on cells because of it's "pinched" shape. SO LDL stays in the blood, and LDL...
by Fiver
Tue Aug 27, 2019 8:47 am
Forum: Science and Research
Topic: APOE4 Carriers Have Memory Problems Before the Onset of Alzheimer's
Replies: 6
Views: 1995

APOE4 Carriers Have Memory Problems Before the Onset of Alzheimer's

Anyone seen this or have comments? APOE4 Carriers Have Memory Problems Before the Onset of Alzheimer's Impaired memory-guided attention in asymptomatic APOE4 carriers Jacqueline Zimmermann, Claude Alain & Chris Butler The paper: https://www.nature.com/articles/s41598-019-44471-1 A summary: https...
by Fiver
Sat Aug 24, 2019 1:38 pm
Forum: Our Stories
Topic: 26 and 4/4
Replies: 11
Views: 2977

Re: 26 and 4/4

Getting freaked out, more or less, is normal. Use it as motivation to take control of your health. The exercise and healthy diets support mental health also - so they might help you to feel better. The shock does fade in time and as you learn more. If it gets too overwhelming get support from family...
by Fiver
Sat Aug 24, 2019 1:25 pm
Forum: Prevention and Treatment
Topic: Epigenetics - can we really turn APOE4 off?
Replies: 30
Views: 7484

Re: Epigenetics - can we really turn APOE4 off?

Oops. Circular is right. My typing skills were never great. :)
by Fiver
Sat Aug 24, 2019 9:51 am
Forum: Prevention and Treatment
Topic: Epigenetics - can we really turn APOE4 off?
Replies: 30
Views: 7484

Re: Epigenetics - can we really turn APOE4 off?

Hi Emerald. It's an interesting question isn't it? As far as I know targeting apoe4 with such precision requires a precision approach, some sort of RNA silencing, gene therapy, or CRISPR technology. Epigenetic approaches to controlling DNA methylation, histone acetylation, or small non-coding RNAs a...
by Fiver
Thu Aug 15, 2019 2:22 pm
Forum: Science and Research
Topic: MIT Tech Review: epigenome editing
Replies: 3
Views: 1061

Re: MIT Tech Review: epigenome editing

Thanks Marc. (sorry, got the "c" right this time)

You're right. I read the wrong paper. Geez. I hope it's just because of the lack of coffee. I'll read this more tonight....

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