Is there any evidence that tau accumulation is reversed by lifestyle changes embodied in RECODE, or are the improvments observed in early AD by following the Bredesen protocol compensatory to a fixed pathology?

Last winter I was happy to find this web group and discover the wealth of information offered herein. Like many others, I have concerns about my risk of developing AD, having watched my mother’s struggles with her ever increasing confusion, anxiety and loss of autonomy leading up to her death at age...

Hi Roxanne, The low weight, high energy, sleeplessness, anxiety and increased blood pressure, as well as increased cholesterol, were all symptoms I experienced one year when I was hyperthyroid (too much thyroid hormone) - probably induced by stress. If you were taking T3, then you probably were unde...

Recently we ordered new test strips for my husband's blood glucose meter. I periodically also check my fasting blood sugar, and noted a lower-than-usual reading with a new test strip. I had one test strip left from the old batch, and found that side-by-side testing of the new strip vs. the old using...

Serum Cholesterol and Incident Alzheimer's Disease Findings From the Adult Changes in Thought Study Markham, et al. J. of the American Geriatric Society, 2018;66(12):2344-2352. This study indicates that what might be considered modestly raised non-HDL cholesterol is associated with the lowest incide...

After reading this book, I added black-out shades to the bedroom windows and turned down the thermostat five degrees before bed. I also removed the clock from the bedroom in an effort not to stir up more concern about how many hours and minutes I have slept. These two articles may be of interest...i...

You may be interested in a discussion with Nir Barzilai, who carried out a small study of centenarians with a succinct gene pool, in which he noted healthy aging despite life style and APOE status. You may have won the genetic jackpot if your parents are both long-lived and aging with relatively goo...

“Physical Activity, Common Brain Pathologies, and Cognition in Community-dwelling older adults” - Neurology, January 16, 2019, Aron Buchman – Rush Memory Aging Project. Using accelerometers, these researchers measured all physical activity (all movement…not just exercise), and found better neurocogn...

“APOE attenuates unresolvable inflammation by complex formation with activated C1q” – Yin, C, et al, Nature Medicine, online 1/28/2019. Study in mice with APOE ko, APOE3 ki and APOE4 ki fed normal chow or high fat chow reveals compromise of blood brain barrier in APOE-ko and in APOE4-ki mice fed hig...

I see no reason to ignore research that is more than five years old unless the methodology has improved or new scientific breakthroughs/insights have led to new testing methods or interpretations. Take a look at the recently discussed Bredesen paper citing research published in 1998. But I do take t...