I know some members here have hypermobility issues. I thought I'd bring this August pre-print to your attention: Folate-Deficient Hypermobility Syndrome I liked this article. "Hypermobility syndrome [has a] suggested prevalence of 2-57% of the population" suggests that additional science ...

Open access review on APOE and neurodegenerative diseases. Or, as one of the authors tweeted: "OUR BIBLE OF APOE IS OUT!" https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-022-00566-4 APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype...

I liked this interview with Jeff Iliff which discussed his work on the glymphatic system and how it may interact with various concerns, including Alzheimer's. STEM-Talk Episode 141: Jeff Iliff on newly discovered system that clears waste from the brain The technical details start at about 16 minutes...

... Also, what % of people die before age 73? It looks like you're saying that 2/3 of 4/4 native americans die before age 73 (.7/2)? Seems a bit high... Source: https://www.ihs.gov/newsroom/factsheets/disparities/ American Indians and Alaska Natives born today have a life expectancy that is 5.5 yea...

Open access. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066743/ Alzheimer's disease drug development pipeline: 2022 Jeffrey Cummings,corresponding author, Garam Lee, Pouyan Nahed, Mina Esmail Zadeh Nojoo Kambar, Kate Zhong, Jorge Fonseca, and Kazem Taghva Alzheimers Dement (N Y). 2022; 8(1): e122...

Hi Mike, you might take some of the timetable inferences from genetic drift (as opposed to specific ancient dna evidence) a little skeptically. See, e.g., a couple of recent review/commentaries from Razib regarding new papers suggesting reinterpretations of population splits. It seems like the scie...

Open access. A review which discusses 9 methods ( hits ) by which APOE4 can damage brains. Extensive references if you want to dig deeper into any of those methods. ( neurodegeneration, neurovascular dysfunction, neuroinflammation, oxidative stress, endosomal trafficking impairments, lipid and cellu...

Greyhound, I could not find the specific biomarkers that this study identified. I pulled up the link and it did not list the biomarkers either. I wonder if these biomarkers correlate with the biomarkers Bredesen follows? Thank you for the posting! Gail, I quickly skimmed the paper https://alz-journ...

Open access paper explores a mechanism by which APOE4 may contribute to AD. https://www.nature.com/articles/s41380-022-01568-w Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy Abdel Ali Belaidi, Shashank Masaldan, Adam Southon, Pawel Kalinowski, Karla Acevedo, Ambili T. Appu...

The author touches on several types of endemic infections that are correlated with AD, but otherwise focuses on other very successful long-term microbial pathogens - particularly Toxoplasma Gondii. I thought it was a interesting summary of a bunch of different types of very common infections we'd be...