I think there is some mistake about comparing these two studies. The first study is a median follow-up period of 8.2 years, in which they evaluate mortality and find it to be increased in the upper quartile of B12. The second study BrianR mentions is a very short term ICU (Intensive Care Unit) analy...

I am a believer in Methylene Blue. The mechanism of action makes tons of sense to me. My biggest problem with it is the mess it makes everywhere. If you showed me pharmaceutical grade pills in the proper dose that don't make a damn mess everywhere, I would probably take it. My whole kitchen is a blu...

I went through the call and notes last night. It was pretty good. I'm going to modify my own exercise regimen around this Zone 2 conditioning framework. The explanations of how lactate works in the body (and its role in cancer) were superb. The discussion really connected a lot of metabolic pathways...

IMO:

Healthcare Provider = OK.
Anyone else not bound by HIPAA or a duty of confidentiality (NDA, etc.) = No.

Interesting. I have a real hard time putting any stock in Table 3. Non-significant confidence intervals. ApoE4 Men who physically exercise having 3.26x the hazard incidence rate than those who are sedentary. Can't simultaneously suggest that low HDL is a biomarker for mortality and that exercising w...

stuff I meant a shift in terms of current utilization of metabolic substrates at that very moment. Not adaptation. You are clearly well adapted. Presumably if a person is not in diabetic ketoacidosis and their ketones are anything north of 2 mM, their metabolism has undergone this metabolic shift a...

If you tested the average person their GKI is probably infinite because their BHB is 0. I don't think Seyfried would distinguish between 0.9 and 1.1. There is likely a difference between 1, 5, 50, 500 & infinity. For example, glucose of 80 and ketones of 0.5 would be a GKI of ((80/18)/.05)=8.9 ...

I would disagree with this a bit. The value of one is where ketones = glucose. Getting ketones > glucose means GKI < 1. The body will use glucose before ketones if it has a choice (mostly to clear it), so to get to a point where your body is properly using ketones, you want to starve the body of gl...

It's just a simple ratio that some person can claim they 'invented' or that they are some 'pioneer' in identifying. Assuming you are not in diabetic ketoacidosis or taking exogenous ketones, what matters most is the absolute level of ketones, such that they are available as an energy substrate and y...