I only have one APOE 4 allele and I managed to have even worse results than that on 3 out of 4 variations of high fat dieting over two years, --so don't fret, it could be worse. You clearly need to make radical changes though. Your elevated TC and LP-PLA2 predispose you for plaque accumulation. Ther...

Welcome to the forum! I know its know its hard to find we carry those old ancestral alleles but you can rest assured there are many 90+ year old 4/4's who still have their wit! I have a feeling you will be one of them. My ' simpleton ' take on how these alleles effect us is two-fold: We are more sen...

[quote="ERK" Yes, did you ever have high sitosterol levels ? My sitosterol was slightly elevated on my last assay. I was at 216 while the top of rang was 169. The deeper story on sterol absorption is how high fat diets can up regulate the rate of sterol absorption. We use those sterols to...

I have a perfect example of phIR from yesterday morning. I got up a bit earlier than usual and so did my wife. We got busy doing things as I continued to drink coffee on an overnight fast. My appetite kind of went away so I didn't eat until several hours later than normal. Now I know from experience...

I'm sorry guys, As much as I'd like to, I don't have time to reply to everything said. Thanks for the suggestion Katie. Yes Susan, there is an abundance of evidence that strongly suggests people with APOE4 poorly metabolize fat and cholesterol compared to other alleles. High cholesterol combined wit...

http://www.newyorker.com/wp-content/uploads/2009/10/091019_r18926a_p646-1200-630.jpg My 12 year old nephew recently enrolled in the school football program. As you might imagine, I'm appalled. I've not expressed my opinion and I'm not sure if I should. I thought the movie "Concussion" wou...

Nice post, MAC. I'm betting my life on it. These guys are experimenting with unorthodox diets advised by mostly fringe doctors. I think they should test until they get it figured out. Eventually, this high fat trend will be long gone...as long as we are testing. I'm confused Hep. Who are "thes...

Agree 100% with Mac and Stavia. Eat less food of higher quality at any macro mix you enjoy, and move more. I agree 100% as well. I would add, pay zero attention to lipids and instead target a lean, muscular body. In my opinion, the lipids should be allowed to take care of themselves. I think the be...

Welcome to the forum Blaise, it so good to have you join us here. Your questions should be answered by your doctor but I have some experience that may help you. Your fast, before the blood draw should be 9-12 hours without food but no longer. I understand, this can be difficult if the draw is not fi...

Hep, thanks so much for taking the time to go thru the paper. Thanks for clarifying that you believe that not all low carb will lead to dangerously high levels of FFA. But I can see that an obese, insulin resistant person will most likeky in the short term at least, have elevated FFAs while losing ...