Thank you for the link -- I also found it kind of reassuring. I believe all the slides, including the one about variation with APOE4, are about dementia in general rather than Alzheimer's specifically. The reason is that their percentage for "everyone" at age 75 is 6%. The table below, fro...

Thanks Dr. Green -- Yes, you're right, I mis-read the article -- I should have used 14 in the calculation rather than 2.24

So in the end, scaling mice to humans, you come up with 50 mg per week, but you reduce it to ~6mg to be conservative. Is that the right way to think about it?

Thanks!

Thank you all --at your suggestion I searched and found other relevant threads, and much useful info was there. Just some amateur "analysis" here, but in the Lin paper they feed the mice 2.24 mg of rapamycin per kg of food eaten. Converting that to human scale, if we eat 2000 calories per ...

New member here. I haven't been able to access the exact paper that Julie G cites above is very impressive, but I stumbled (via the website of Dr. Alan Green) upon the paper linked below, which I think is maybe a slightly updated version, probably the same authors, etc. It is a *very* impressive pap...