I have a lot of familiarity with this drug and I have physically manufactured it in the lab with my own hands (along with several other anti-Abeta antibodies). I've read dozens of the research papers on this antibody. I think this is a horrible precedence by the FDA, because they've approved it not ...

I also got an Oura ring about 3 months ago, and I've been having fun performing experiments on myself to see what affects my sleep! Deep sleep normally happens in the first third of the night, starting soon after you go to bed. So I find it's very important what you're routine is right before bed. F...

I finished it this morning (it's a little over 2 hours). If you're just interested in the practical advice, it all comes in the last 20 minutes or so. The guest is a very conservative scientist, which I love. For example, he states that consumption of DHA-rich fatty fish does appear to reduce likeli...

I'm about a third of the way into this podcast, and so far it is excellent.

https://peterattiamd.com/husseinyassine/

Just came out today (Feb.1 2021).

This is nothing new, but it's always good to get confirmation! Also, this is a long-term study with many participants. For those that don't know, "glycemic load" is essentially eating a lot of carbs (more technically, something that you ingest that raises your blood glucose). In this study...

I listened to this over the weekend, and it is fantastic! A lot of ApoE4-specific content. It's quite long (>2 hours), but worth it.

Just published in JAMA are results from a large study examining a blood marker for early detection of Alzheimer Disease. The marker is P-tau217, and it appears to be elevated up to 20 years before any symptoms. Surprisingly, no mention of ApoE status of the participants. Here's the paper: https://ja...

https://www.biospace.com/article/-nih-f ... s-disease/

They're going to look at proteins that specifically interact with ApoE4 (or fragments thereof). I don't see a lot of research specifically aimed at ApoE4, so this is nice to see.

Having been in the trenches in research around the amyloid hypothesis heyday in the mid-2000's, I don't really think there was a concerted effort to ignore all other possibilities. That's just typical of science in general. The "hot" hypothesis gets all of the attention (and funds). The da...

Why on earth did they do the trial where the control group was dosed at 8 mg/day? There had to be some rational reason, because these trials are very expensive to run. Sounds like a new trial does need to be done with better controls. I don't think the FDA could approve a treatment based on a trial...