Thanks. very interesting! I think this is what I am learning: Looks like several things might be going on. Cell shrink and swell, which would involve the aquaporins to let water in and out of cells. Then there is some sort of space, tubes or openings. And these become more open or more constricted d...

Thanks Julie. That's also a interesting site. (when I saw that they list statins as having solid evidence supporting moderate benefit I imagined the debate that might cause, though it does seem - at least to me - to be an accurate rating). It is interesting what happens in society as evidence for no...

Anyone seen this yet? I read the report, which reads like a journal review article but as far as I can tell is not published in a peer-reviewed journal. But it seems useful and legit, ranking various non-pharmacological interventions by the strength of supporting evidence. Link Below. Washington, D...

Don't worry too much about whether or not anyone "is confused" about blood cholesterol and lipids. I know highly trained cardiologists and lipodemiologists who admit that *no one* understands this. We're all trying to make the best possible choices with incomplete information. It seems lik...

Sometimes I can absorb data like this objectively and scientifically. Sometimes my first response is a wave a dread and worry. Depends on the day. My calcium score was zero - which was reassuring. But I have had close relatives have early life heart attacks too. I try to use statements like this to ...

Totally normal. Sounds like you are using the information to improve your health overall. That's the good part of this wild ride.

I guess this new news article relates to our discussion of epigenetics.... First hint that body’s ‘biological age’ can be reversed In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’, which tracks a person’s biological age. https://www.nature.com/articles/d41586-019-02638-w?ut...

I've often wondered how this would work. The connections must be small and there must be some positive pressure from the brain, pushing fluid outward - else pathogens could get in. Seems like the flow of substances out of the brain would depend upon the size of the "tubes" and the pressure...

Hi Michae_M. I recall being encouraged by the structure corrector studies a few years back but so far it does not seem to have made much progress. It seems the biotech companies of finding more difficult than anticipated in people, compared to cell culture and mice. this approach seems to have the o...

Hi Julie, I was trying to get through this one yesterday and got side-tracked. I'd believe epi-genetics is a part of it. Though the work on the genes themselves - apoe4 and others - is also pretty convincing. There are three basic epi-genetic systems, which place or remove "epigenetic" mar...