adriana268 wrote:hello! I recently completed a 23 and me genetic analysis and found I have a mutation in my mthfd1 (and PEMT) that predisposes me to choline deficiency. Seeing that acetylcholine is essential for sleep, emotional well being and has an important role in alzheimer, I was wondering if anyone here takes choline supplementation, has the gene or has more information of this connection. I can't seem to find much online. I've always suffered from sleep issues and some mental fog so I am wondering if this is related
HNorthrup wrote:In Julian Whitaker, MD's natural health newsletters back in 2003 and 2005, he stated that, if we can't get enough choline from our diet (e.g., chicken breast, salmon, eggs), he recommended taking phosphatidylcholine or alpha-GPC instead of choline. Here's an excerpt:
"...to ensure optimal intake, nothing beats choline supplements. The best of these is phosphatidylcholine
(PC), a water-soluble form that is easier on the gastrointestinal tract than straight choline. There’s a new form
of PC called alpha-glycerylphosphorylcholine (alpha-GPC) that is actually the neurons’ preferred form of choline.
When levels of acetylcholine are low, PC in the cell membranes is broken down into alpha-GPC, which is then used
to create acetylcholine. Supplementation with PC has been shown in many studies to improve choline metabolism,
boost brain levels of acetylcholine, and improve alertness, information processing, and other measures of
cognitive function. In addition to protecting against age-related cognitive impairment, GPC also helps mitigate the devastating effects of brain trauma, stroke, and Alzheimer’s."
Users browsing this forum: No registered users and 5 guests