Theresa, thank you, thank you, thank you! Excellent summary. You captured it all.
I learn something every time I listen to Dr. Bredesen speak. He gives me so much hope. The only issue I have is when he says that Apoe4 homozygotes have a 90 percent chance of getting Alzheimer's.
I recently spoke with Doris Zallen and she told me that the risk figure is 40-55 percent for homozygotes by age 85, according to the Alzheimer's Prevention Initiative (API) of the Banner Alzheimer's Institute in Phoenix, AZ.
Doris is the professor in the Department of Science and Technology in Society at Virginia Tech who is conducting the study called “Genetic Testing for Common Disorders: Learning from the Experiences of Individuals who were Tested to Determine their Genetic Risk for Alzheimer’s Disease.”
I would like to follow up with Dr. Bredesen and ask him where his 90 percent figure comes from. Maybe it would be 90 percent if homozygotes never died of anything else and lived to 120 years of age? Of course, he intends for any risk figure to decrease for homozygotes and heterozygotes alike as a result of his pioneering work.
ApoE 4/4 - When I was in 7th grade, my fellow students in history class called me "The Brain" because I had such a memory for detail. I excelled at memorization and aced tests. This childhood memory helps me cope!