GoldenGirl wrote:I am interested in participating. I’m e4/e4, 48 yrs old. Thanks!
Trevor wrote:I'm a 4/4 that'd be interested in participating if I'm not too young (35) or Canadian.
MargaretE wrote:I am interested in participating. I'm E4/4, 74 years old.
Marinochka wrote:I am interested in participating too. I am e4/4, 53 years old. My husband can join too. He is e3/4, 56 years old.
dancingbluefish wrote: I found out I'm APO4/3 carrier from 23&me about 2 years ago...I am also interested in the study. Thanks.
Hello to all of you!
As a Senior Support Team member, and someone with ApoE 4/4 who has participated in a clinical trial for Alzheimer's prevention (the Generations trial), I want to applaud all of you for your interest in this study opportunity. At this point, the study has not been started; the post was an introductory effort to gauge interest.
Here's a great explanation of Biomarkers, which this Topics mentions, by our Primer author and Doctor, Stavia: Primer: Biomarkers
. For a deeper dive and more detail on each biomarker, see this Wiki: Biomarkers
Most of these tests can be ordered by your doctor or by you online--less so in Canada, Trevor. Here's a link to that topic in our Wiki: Direct to Consumer Lab Testing Options
For clinical trials that might measure biomarkers or use interventions to see how biomarkers change, you can use several resources:
The All of Us Research Program
is sponsored by the National Institute of Health: All of Us
inviting one million people across the U.S. to help build one of the most diverse health databases in history. We welcome participants from all backgrounds. Researchers will use the data to learn how our biology, lifestyle, and environment affect health. This could help them develop better treatments and ways to prevent different diseases.
The Alzheimer's Association spends millions each year to support research on prevention and treatment of AD, and has a Trial Match of studies that include non-drug trials. You can read more here: Trial Match
The Alzheimer's Clinical Trial Consortium (ACTC) is a network of dozens of academic research centers collaborating to accelerate research, with funding from the National Institute on Aging (NIA/NIH). They have an online web study called APT Webstudy
for people who are 50 years or older. APT Webstudy Welcome
You do not have to have ApoE 4 and are under no obligation to participate in future clinical trials. Some people may be invited to a regional center for screening to determine if they might be eligible for a clinical trial. (Full disclosure: I am on the Research Participant Advisory Board for the ACTC, although I am not in any ACTC-sponsored clinical trial.)
To search for clinical trials (large and small) by your region, try the advanced search function on the NIH Clinical Trials website. Each trial has detailed information about its purpose, the criteria to join and contacts for study sites. Clinical Trials.gov
Enjoy learning more about biomarkers and clinical trials--and ask questions any time!