URGENT: Biomarker Study Opportunity for ApoE4.Info Members
Posted: Sun Mar 31, 2019 5:52 am
Hi Friends! Over the past year, we’ve been collaborating with Prodrome Sciences and OpenCures on a project to advance APOE-ε4 science. ApoE4.Info members who choose to participate will receive quarterly reports of levels of hundreds of metabolites, proteins, and standard clinical biomarkers to help us refine our personal health strategies. Our anonymized data will inform the development of prevention and treatment strategies for all ε4 carriers and comprise an open access database available to all researchers.
The testing will be extraordinarily detailed and will provide information measured and used by scientists but not yet clinically available at any price. At a cellular level, what is happening in our bodies? Does the latest research associate our metabolomic profiles with vibrant health and longevity or with chronic disease and increased mortality? As we adapt strategies to mitigate the effect of our APOE-ε4 status, what happens to our metabolomes? Do specific strategies help or hurt? We will be able to conduct our own N=1 personal experiments, to discuss and share our experiences with others, and to access the anonymized data of all participants.
Metabolomic links to specific diseases is a hot research topic, and we will receive results that help us evaluate and potentially alter our own prospects for Alzheimer’s, heart disease, colorectal cancer, pancreatic cancer, and overall longevity.
Optionally, each participant will be able to try a new supplement designed to boost a key family of the measured metabolites. You can learn more about the links among plasmalogen levels, Alzheimer’s risk, and APOE-ε4 status from the slide deck attached to the first post of this topic.
Full details including testing scope, report samples, and costs are still being developed. The metabolomic testing will be donated by Prodrome Sciences, and we will enjoy favorable pricing for the standard clinical tests. Currently our convenient in-home phlebotomy solution accounts for most of the expense. We are exploring options to allow individual participants to reduce the cost, which we expect to come in above $50 and below $125 monthly over the minimum two year participation period.
What you will need to provide:
To weigh in, please respond to the poll above in this topic.
The testing will be extraordinarily detailed and will provide information measured and used by scientists but not yet clinically available at any price. At a cellular level, what is happening in our bodies? Does the latest research associate our metabolomic profiles with vibrant health and longevity or with chronic disease and increased mortality? As we adapt strategies to mitigate the effect of our APOE-ε4 status, what happens to our metabolomes? Do specific strategies help or hurt? We will be able to conduct our own N=1 personal experiments, to discuss and share our experiences with others, and to access the anonymized data of all participants.
Metabolomic links to specific diseases is a hot research topic, and we will receive results that help us evaluate and potentially alter our own prospects for Alzheimer’s, heart disease, colorectal cancer, pancreatic cancer, and overall longevity.
Optionally, each participant will be able to try a new supplement designed to boost a key family of the measured metabolites. You can learn more about the links among plasmalogen levels, Alzheimer’s risk, and APOE-ε4 status from the slide deck attached to the first post of this topic.
Full details including testing scope, report samples, and costs are still being developed. The metabolomic testing will be donated by Prodrome Sciences, and we will enjoy favorable pricing for the standard clinical tests. Currently our convenient in-home phlebotomy solution accounts for most of the expense. We are exploring options to allow individual participants to reduce the cost, which we expect to come in above $50 and below $125 monthly over the minimum two year participation period.
What you will need to provide:
- -Quarterly blood draws with a phlebotomist coming to your home or to a central location near you.
-Quarterly anthropometric data including height, weight, blood pressure
-Quarterly online cognitive testing
-Quarterly reporting of your lifestyle strategies, diet details, and supplements
To weigh in, please respond to the poll above in this topic.