CoachMT wrote:Azawakh1 wrote:Is it too late?
Welcome to the to the Apoe4.info community Azawakh! Great to hear you are interested in participating in the Biomarker study!
If you haven’t checked it out already, the primer, however if you haven’t yet, it’s a great place to learn about the resources available on this site. It was authored by a member physician who also carries two copies of the APOE-ε4 allele. It is regularly updated and provides information on the science behind the APOE-ε4 allele, tips on diet and lifestyle choices, biomarkers to check, and prevention strategies. Additionally, you may also be interested in checking out Our Stories to learn about fellow community members and to share with fellow members a little bit about your own story.
Welcome and please don’t hesitate to ask questions.
Julie G wrote:Hi Friends! Over the past year, we’ve been collaborating with Prodrome Sciences and OpenCures on a project to advance APOE-ε4 science. ApoE4.Info members who choose to participate will receive quarterly reports of levels of hundreds of metabolites, proteins, and standard clinical biomarkers to help us refine our personal health strategies. Our anonymized data will inform the development of prevention and treatment strategies for all ε4 carriers and comprise an open access database available to all researchers.
The testing will be extraordinarily detailed and will provide information measured and used by scientists but not yet clinically available at any price. At a cellular level, what is happening in our bodies? Does the latest research associate our metabolomic profiles with vibrant health and longevity or with chronic disease and increased mortality? As we adapt strategies to mitigate the effect of our APOE-ε4 status, what happens to our metabolomes? Do specific strategies help or hurt? We will be able to conduct our own N=1 personal experiments, to discuss and share our experiences with others, and to access the anonymized data of all participants.
Metabolomic links to specific diseases is a hot research topic, and we will receive results that help us evaluate and potentially alter our own prospects for Alzheimer’s, heart disease, colorectal cancer, pancreatic cancer, and overall longevity.
Optionally, each participant will be able to try a new supplement designed to boost a key family of the measured metabolites. You can learn more about the links among plasmalogen levels, Alzheimer’s risk, and APOE-ε4 status from the slide deck attached to the first post of this topic.
Full details including testing scope, report samples, and costs are still being developed. The metabolomic testing will be donated by Prodrome Sciences, and we will enjoy favorable pricing for the standard clinical tests. Currently our convenient in-home phlebotomy solution accounts for most of the expense. We are exploring options to allow individual participants to reduce the cost, which we expect to come in above $50 and below $125 monthly over the minimum two year participation period.
What you will need to provide:
-Quarterly blood draws with a phlebotomist coming to your home or to a central location near you.Participation will not be limited to ε4 carriers. We are especially interested in including non-ε4 family members. The project is not imminent; however, we do need a preliminary assessment of member interest for an NIH grant application that is due soon. Grant funds could reduce member cost, enrich the information we receive, or both.
-Quarterly anthropometric data including height, weight, blood pressure
-Quarterly online cognitive testing
-Quarterly reporting of your lifestyle strategies, diet details, and supplements
To weigh in, please respond to the poll above in this topic.
Triple7s wrote:I'm in as well.
Triple7s wrote:I'm in as well.
Suzp wrote:I would very much like to participate in the Biomarker Study if still possible. I am an ApoE4 carrier and new to the group.
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