poppela1958 wrote:I am interested, I am E3/E4 with my father, grandmother and two great grandmother's who were diagnosed with either Alzheimer's or senility. I know at least two siblings that would be interested as well.
If you are like me and snuck in a reference to your birth year in your user name, let me be the first to reassure you that at almost 67, and ApoE 4/4, I am still doing just fine both cognitively and in enjoying life! That's more than I could hope for when I was about to turn 62 and found out my 4/4 status--because the "news" was that probably I would be diagnosed with Alzheimer's disease by age 68. And yet here I am, enrolled in a clinical preventions study that requires people with Apoe 3/4 or 4/4 to be cognitively healthy and ages 60-75--and I still do just fine on the semi-annual tests. And my early diet, exercise schedule and stress level was far from perfect and like you, I have a history of heart disease and dementia on both sides.
So let me first repeat our favorite mantra: Genes are not destiny! We have many more protective factors than previous generations did. Our food is healthier, most of us are less exposed to smoke, toxic water, lead and other pollutants. We had more education than our grandmothers and great-grandmothers, which gives us cognitive reserve that is associated with 7 more years of good cognition in some studies. We have access to health care to keep our blood pressure down, our glucose and insulin levels normal and to prevent heart disease and chronic sleep apnea. And of course, we have the ability to find what works for us and what is recommended for people with ApoE 4 and to intervene early to help ourselves!
We're glad you found our site and hope this information and other forum topics are helpful. If your siblings are interested in this biomarker study, they are certainly welcome. If they haven't been tested for ApoE 4, you may want to share this link with them; it presents a balanced view of getting tested: Thinking About Testing?
Since this is your first post, I would encourage you to spend some time checking out these handy links:
We encourage new users to share their own stories of finding out about ApoE4, their own best practices to enjoy a healthy life and any questions or favorite topics on Our Stories
is an easy-to-browse resource with topic headings of topics related to strategies to understand and manage risk that you can begin at a pace that works for you. "How-To" Get the most out of the ApoE4.info website
is a great resource for new users. It shows screen shots of how to quote users so they will see your posts, how to search topics and how to use our Wiki
Feel free to jump into any conversation; we welcome the views and lived wisdom of all our members and are here to support each other in finding out how to best respond to this inheritance of ours!