Gene Therapy Trial for ApoE4 Homozygotes

Elevation
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Re: Gene Therapy Trial for ApoE4 Homozygotes

Postby Elevation » Mon May 31, 2021 8:52 am

I believe this same study is now being offered in a research facility in Orlando.
Same requirements.

Sarah Poissant
Patient Recruitment
100 W Gore Street Suite 202 Orlando FL 32806
Phone: 689-216-3179
Fax: 407-386-9305
Email: Sarah.Poissant@ppd.com
Website: www.ppd.com
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Re: Gene Therapy Trial for ApoE4 Homozygotes

Postby NF52 » Mon May 31, 2021 9:06 am

Elevation wrote:I believe this same study is now being offered in a research facility in Orlando.
Same requirements.

Sarah Poissant
Patient Recruitment
100 W Gore Street Suite 202 Orlando FL 32806
Phone: 689-216-3179
Fax: 407-386-9305
Email: Sarah.Poissant@ppd.com
Website: http://www.ppd.com
Follow us on Facebook PPD Clinical Research Unit - Orlando, FL - Home | Facebook

Elevation
Hi Elevation, I'm not sure what the source of your information was, but it seems inaccurate. The website for PPD Orlando Clinical study opportunities currently shows no trials of any kind.
https://www.ppd.com/participate-in-clin ... rtunities/

The Clinical Trials.gov website for this trial was last updated on April 21 and continues to show only the Weill Cornell Medical Center in NYC as the sole site: https://clinicaltrials.gov/ct2/show/NCT ... 1#contacts
4/4 and still an optimist!

Elevation
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Re: Gene Therapy Trial for ApoE4 Homozygotes

Postby Elevation » Mon May 31, 2021 11:58 am

I received a call from Sarah recently informing me of this study....I questioned her...she assured me it was the same study. I did not proceed so don’t really know more.

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Re: Gene Therapy Trial for ApoE4 Homozygotes

Postby NF52 » Mon May 31, 2021 12:18 pm

Elevation wrote:I received a call from Sarah recently informing me of this study....I questioned her...she assured me it was the same study. I did not proceed so don’t really know more.

Maybe they haven’t updated their web page. I saw that in another site regarding a study I knew they were doing.
It’s a fascinating study—but I don’t think I’d be brave enough to sign up!
4/4 and still an optimist!

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Re: Gene Therapy Trial for ApoE4 Homozygotes

Postby Brian4 » Wed Sep 08, 2021 7:46 pm

ApropoE4 wrote:Results from a second generation investigational gene therapy program show effective delivery of APOE2, the gene associated with protection against the development of Alzheimer's disease, while also targeting and silencing APOE4, the gene that increases risk of developing the disease. A 40% reduction was observed in APOE4 expression, while APOE2 expression was maintained, suggesting APOE2 was resistant to microRNAs (miRNAs) silencing. The efficacy of gene silencing by miRNAs targeting APOE4 was evaluated by inserting miRNA into the AAV vector expression cassette.

Hey ApropoE4, and thanks for this!

I just noticed there are two new gene therapy candidates listed at Lexeo's website:

LX1020 Alzheimer's APOE2+ /E4-
LX1021 Alzheimer's Christchurch

I assume you're referring to LX1020 – though perhaps a different research group is working on something similar.

In any event, very exciting research! (I think I'll wait for the Christchurch variant to be available.)

Brian

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Re: Gene Therapy Trial for ApoE4 Homozygotes

Postby ApropoE4 » Sat Sep 11, 2021 12:29 pm

I think the study was / is for LX1001, but they just raised $100mm for further trials (I believe including LX1020 and 1021)

https://www.lexeotx.com/post/lexeo-ther ... -financing


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