This is promising! Cellular senescence occurs when normal cells fail to divide. Despite no longer dividing, they remain metabolically active and tend to take on a pro-inflammatory phenotype contributing to aging. As we age, our brain cells also display senescent-like changes and accumulate. Work with mice has shown that drugs targeted at senescent cells prevents tau build-up, protecting neurons. Scientists in England have found that a common antibiotic, azithromycon, can effectively target and eliminate senescent cells in culture. At a single low-dosage, Azithromycin was shown to effectively kill and eliminate the senescent cells, with an efficiency of 97 percent. Moreover, the normal healthy cells thrived in the presence of Azithromycin.
Here’s the press release: Antibiotics eliminate senescent cells associated with ageing
Here’s the paper: Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts