J11 wrote:Great article! Will need to read the fine print, though, as they introduce a fair number of new concepts
anotherdreamer wrote:I attempted to read the full article here: https://journals.plos.org/plosgenetics/ ... en.1008612 but a lot of the science went over my head. Since you clearly have a better grasp of this, would you mind answering a question?
This is from the article:
"For Alzheimer’s disease, our estimate of the liability-scale SNP heritability for the full 2013 dataset  is 15% for prevalence of 14% for those aged 71 older, half from APOE, while the recent “M2” and “M3” models of Zhang et al  gave values of 7% and 10% respectively–see S1 Appendix (p. S13)."
Does this mean that they believe only about 15% of AD is from genes? And that only half of that is from APOE? Or am I completely misunderstanding this?
floramaria wrote:J11 wrote:anotherdreamer, when you are hoping for a direct response from someone who post you are responding to it is helpful to use the quote function. You can find info on this and other helpful hints for navigating the website most effectively at How-To Get the Most out of the ApoE4.info website
You are welcome!anotherdreamer wrote:Thank you, Floramaria! I didn't realize you had to be quoted to get an alert.
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