In addition to this website, we (ApoE4.info) has a Facebook page where articles on current research are posted. Here are the top 10 links posted that generated the most interest during the first quarter (Jan – Mar) of this year.
1. Posted Feb 8, 2021
Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies
Caffeine – maybe, maybe not. “Alzheimer’s disease (AD) is the most common type of dementia leading to progressive memory loss and cognitive impairment. Considering that pharmacological treatment options for AD are few and not satisfactory, increasing attention is being paid to dietary components that may affect the development of the disease. Such a dietary component may be caffeine contained in coffee, tea or energy drinks. Although epidemiological data suggest that caffeine intake may counteract the development of cognitive impairment, results of those studies are not conclusive. The aim of the present study is to review the existing experimental studies on the efficacy of caffeine against AD and AD-related cognitive impairment, focusing on the proposed protective mechanisms of action. In conclusion, the reports of studies on experimental AD models generally supported the notion that caffeine may exert some beneficial effects in AD. However, further studies are necessary to elucidate the role of caffeine in the effects of its sources on cognition and possibly AD risk.”
direct link: https://www.mdpi.com/2072-6643/13/2/537 ... MV7i1xGw40
2. Posted Jan 9, 2021
Biotin, mitochondria, and dementia: Research reveals a connection
"New research, just published in PNAS, now shows that some forms of severe neurodegeneration, like the frontotemporal dementia seen in Alzheimer's and Parkinson's, can directly result from lack of sufficient biotin."
direct link: https://medicalxpress.com/news/2021-01- ... QTNZ0puVKM
3. Posted Jan 5, 2021
Dr. Sanjay Gupta's prescription for fighting off dementia
Dr Gupta believes that there are lifestyle changes we can employ that can absolutely delay the progression of dementia, and even reverse it. “Dr. Gupta said the key is doing activities that create "cognitive reserves" in the brain — areas of new nerve growth and wiring that can pick up the slack if needed.” Anyone planning on reading his soon to be released book “Keep Sharp?”
Direct link: https://www.cbsnews.com/news/sanjay-gup ... 54z4I6zecw
4. Posted Jan 17, 2021
Better diet and glucose uptake in the brain lead to longer life in fruit flies
ApoE4s tend to develop impaired glucose uptake in the brain. From this paper, researchers found that in fruit flies, “better glucose uptake compensates for age-related deterioration in motor functions, and led to longer life.” If that translates to humans, that might explain why we as ApoE4s also tend to suffer from shortened longevity. But this also means that from these findings, “The effect was more pronounced when coupled with dietary restrictions. That suggests healthier eating plus improved glucose uptake in the brain might lead to enhanced lifespans.”
Direct link: https://www.eurekalert.org/pub_releases ... 1X2Sb1BfHY
5. Posted Jan 27, 2021
The Immunopathogenesis of Alzheimer’s Disease Is Related to the Composition of Gut Microbiota
Alzheimer’s starts in the gut. Yup, that’s what this paper says. How? Our body is host to trillions of microorganisms. This is typically a mutually advantageous relationship. 70% of these microorganisms reside in the gastrointestinal tract. But dysbiosis occurs when “bad” gut bugs overtake the “good” gut bugs. While often imperceptible, the body reacts to this, the immune system intervenes producing inflammation, and ApoE4s are already pro-inflammatory. That, in turn triggers neuroinflammation and finally neurodegeneration. Additionally, imbalanced gut bug composition can impair the intake and metabolism of nutrients. From the abstract of this paper, “In patients with Alzheimer’s disease (AD) significant alterations of the gut microbiota [bugs] have been demonstrated. Standard Western diet, infections, decreased physical activity and chronic stress impact the composition and diversity of gut microbiota.” It also says, "Modulation of gut microbiota by Mediterranean diet, probiotics and curcumin can slow down cognitive decline and alter the gut microbiome significantly.'
Direct link: https://www.mdpi.com/2072-6643/13/2/361 ... uYC_BWriwk
6. Posted Jan 1, 2021
Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease
Resveratrol is a polyphenol found in red wine and many plants. It has certain neuroprotective effects, except many resveratrol supplements are ineffective because of lack of bioavailability. “Resveratrol plays an important role in promotion of non-amyloidogenic cleavage of the amyloid precursor protein. It also enhances the clearance of amyloid beta-peptides and reduces the damage of neurons. Most experimental research on AD and resveratrol has been performed in many species, both in vitro and in vivo, during the last few years. Nevertheless, resveratrol’s effects are restricted by its bioavailability in the reservoir. Therefore, scientists have tried to improve its efficiency by using different methods. This review focuses on recent work done on the cell and animal cultures and also focuses on the neuroprotective molecular mechanisms of resveratrol. It also discusses about the therapeutic potential onto the treatment of AD.”
Direct Link: https://www.frontiersin.org/articles/10 ... qbczIYexIU
7. Posted Mar 27, 2021
UArizona researcher finds a unique approach to tackle both Alzheimer’s disease and diabetes]
A University of Arizona Health Sciences researcher examined the role of cholesterol in both Alzheimer's disease and Type 2 diabetes to identify a small molecule that may help regulate cholesterol levels in the brain, making it a potential new therapeutic target for Alzheimer's disease.
Direct Link: https://www.news-medical.net/news/20210 ... g4PWkky5T8
8. Posted Jan 14, 2021
Rotten egg gas could guard against Alzheimer's disease
Whatever works, I guess. “In experiments in mice, researchers have shown the foul-smelling gas may help protect aging brain cells against Alzheimer's disease. The discovery of the biochemical reactions that make this possible opens doors to the development of new drugs to combat neurodegenerative disease.”
Direct Link: https://www.eurekalert.org/pub_releases ... Y8xEsk3F6U
9. Posted Jan 26, 2021
Study Shows the Relationship Between Surgery and Alzheimer’s Disease
For goodness sake, if you need major surgery, have major surgery. But this may be something you'd wish to discuss with your doctor. This new study published in the Journal of Alzheimer’s Disease carried out by researchers at the Marqués de Valdecilla-IDIVAL University Hospital, in collaboration with researchers at the University of Bonn Medical Center, proposes that major surgery is a promoter or accelerator of Alzheimer’s disease (AD).
Direct Link: https://neurosciencenews.com/alzheimers ... ZFZNBnIBIM
10. Posted Jan 10, 2021
Alzheimer’s brain tissue study uncovers three distinct disease subtypes
More evidence that Alzheimer’s Disease isn’t ONE disease. From these findings, only one third of the cases studied displayed “typical” Alzheimer’s hallmarks. “The new research set out to understand the specific molecular characteristics of different Alzheimer’s cases. Using RNA sequencing the research analyzed over 1,500 brain tissue samples, spanning five different brain regions.
Three major molecular subtypes of Alzheimer’s were identified based on factors including synaptic signaling, immune activity, mitochondria organization, myelination and specific gene activity. … The challenge moving forward will be to find ways to detect these disease subtypes easily in living patients.”
Direct Link: https://newatlas.com/science/alzheimers ... _37E0fdbKo